深圳市健康人群白喉 百日咳 破伤风抗体水平监测  

Surveillance on Antibody Levels of Diphtheria Pertusis and Tetanus in Health Population in Shenzhen

作　　者：刘跃红[1] 卢紫燕[1] 单芙香[1] 谭洁[1] 罗青山[1] 曾华堂[1] 

机构地区：[1]深圳市疾病预防控制中心,广东深圳518020

出　　处：《中国疫苗和免疫》2009年第3期226-228,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解深圳市健康人群白喉、百日咳、破伤风抗体水平和百日咳-白喉-破伤风联合疫苗(Diphtheria,Tetanus,Pertussis Combined Vaccine;DPT)的免疫效果,为制订DPT免疫策略提供依据。方法百日咳抗体检测采用微量凝集试验法,白喉、破伤风抗体检测均采用间接血凝试验法。结果检测的650人中,白喉抗体阳性率为88.31%,保护率为87.38%,几何平均浓度(Geometric Mean Concentration,GMC)为0.2595IU/ml(国际单位/毫升);破伤风抗体阳性率为71.54%,保护率为64.15%,GMC为0.5607IU/ml;百日咳抗体阳性率为92.77%,保护率为37.23%,几何平均滴度为1:156.87。结论儿童完成DPT基础免疫后,1.5～2岁DPT加强免疫和小学一年级学生白喉-破伤风联合疫苗(Diphtheria,Tetanus Combined Vaccine;DT)加强免疫收到了良好的效果。因抗体水平随着年龄的增长呈下降的趋势,>10岁以后抗体明显下降,故需对初中一年级学生、高中三年级学生或大学新生、成人接种降低抗原含量的DT进行加强免疫。Objective To know the antibody levels of DDT and the immunization effect of DPT vaccine in health population in Shenzhen, and to provide theoretic basis for the immunization strategy of DPT. Methods Antibody of pertusis was tested by agglutination tests, antibodies of diphtheria and tetanus were tested by IHA tests. Results The antibody positive rate of diphtheria, pertusis and tetanus were 88.31%, 71.54% and 92.77% respectively. The protective rate were 87.38%, 64.15% and 37.23% respectively. The GMT of diphtheria, pertusis and tetanus were 0.259 5,0.560 7 and 1：156.87 respectively. Concision The antibody levels of diphtheria, pertusis and tetanus decreased by age, we should carry out DT booster immunization in freshmen of middle school, colleges and adults.

关 键 词：百日咳抗体 白喉抗体 破伤风抗体 监测 

分 类 号：R515.6[医药卫生—内科学] R517.1[医药卫生—临床医学]