北京市2007年健康人群脊髓灰质炎抗体水平分析  

Analysis of Polio Antibody Levels in Healthy Population in Beijing in 2007

作　　者：李晓梅[1] 张合润[1] 王玉梅[1] 刘东磊[1] 邹艳杰[2] 王冬梅[3] 徐若辉[4] 刘方[5] 王海红[6] 蒋贵英[7] 张曙光 纪文艳[1] 

机构地区：[1]北京市疾病预防控制中心,北京100013 [2]北京市东城区疾病预防控制中心,北京100009 [3]北京市宣武区疾病预防控制中心,北京100053 [4]北京市海淀区疾病预防控制中心,北京100037 [5]北京市朝阳区疾病预防控制中心,北京100021 [6]北京市昌平区疾病预防控制中心,北京101220 [7]北京市怀柔区疾病预防控制中心,北京101400 [8]延庆县疾病预防控制中心,北京延庆102100

出　　处：《中国疫苗和免疫》2009年第3期245-248,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解北京市2007年健康人群脊髓灰质炎(脊灰)抗体水平。方法采用分层多级抽样的方法,调查北京市7个区(县)的<1、1～4、5～9、10～14、15～19、20～24、25～29、30～34、35～39、≥40岁健康人群共1552人,用微量细胞中和试验测定血清脊灰中和抗体。结果脊灰中和抗体Ⅰ、Ⅱ、Ⅲ型阳性率分别为97.04%、97.29%、91.04%;抗体几何平均滴度(Geometric Mean Titers,GMT)分别为1:70.05、1:54.60、1:31.83。抗体GMT随年龄增长和免疫后时间延长而逐渐下降。不同性别、户籍、地区间抗体水平差异无显著的统计学意义。多因素分析发现,年龄组和免疫后时间对抗体GMT的影响有统计学意义。结论北京市健康人群对脊灰形成了免疫屏障。Objective To investigate the poliomyelitis antibody level in healthy people in Beijing. Methods 10 age groups （0, 1 to 4, 5 to 9, 10 to 14, 15 to 19, 20 to 24, 25 to 29, 30 to 34, 35 to 39, and ≥ 40） were sampled by the Multi-stage stratified sampling method in 7 districts in Beijing, and 1552 sera from healthy population were collected. The poliomyelitis antibody was determined with microcell neutralization method. Results The neutralized antibody-positive rate for polio Ⅰ,Ⅱ,Ⅲ were 97.04%, 97.29% and 91.04% respectively, the geometric mean titers （GMT） were 1：70.05, 1：54.60, and1：31.83 respectively. A trend of decreasing was observed in the GMTs with increasing age and years after immunization. There were no significant differences in antibody levels between different gender, residents or regions. The results of multiple-factors analysis showed that the GMTs were significantly associated with age and the years after immunization. Conclusion A stable immunization barrier has been established in healthy population in Beijing.

关 键 词：脊髓灰质炎 中和抗体 阳性率 几何平均滴度 

分 类 号：R512.4[医药卫生—内科学] R186[医药卫生—临床医学]