卡波氏肉瘤相关病毒编码的miRNAs的研究进展  

Progresses of KSHV-Encoded miRNAs in Kaposi Sacoma

作　　者：张国宁[1] 谭晓华[1] 李冬妹[1] 杨磊[1,2] 

机构地区：[1]石河子大学医学院,中国新疆石河子832000 [2]杭州师范大学医药卫生管理学院,中国浙江杭州310036

出　　处：《生命科学研究》2009年第3期278-282,共5页Life Science Research

基　　金：国际科技合作项目(2005DFA30780)

摘　　要：MicroRNAs(miRNAs)是由内源性基因编码的转录后调节基因表达的小分子RNAs,可与靶基因mRNAs的3′非翻译区互补结合,抑制翻译.最近,在卡波氏肉瘤相关病毒(Kaposi sarcoma-associatedherpesvirus,KSHV)的基因组中鉴定出12条miRNAs编码基因,这些病毒的miRNAs可能作用病毒本身,也可能调节宿主细胞的基因表达.然而,对它们的功能仍然所知甚少.主要介绍卡波氏肉瘤相关病毒KSHV(HHV8)编码的miRNAs对宿主细胞基因表达的干预,并探讨病毒miRNAs在病毒发病机理中的可能的作用途径.miRNAs（miRNAs） are small noncoding RNAs that post-transcriptionally regulate gene expression by binding to 3＇-untranslated regions （3＇UTRs） of target mRNAs, inhibiting their translation. Recently, 12 miRNA genes have been identified within the genome of Kaposi sarcoma-associated herpesvirus （KSHV）. These miRNAs may possibly not only act on KSHV＇s own mRNA, but also regulate host cell＇s genes expression. However, only few of their functions are known. The interference effect of KSHV-encoded miRNAs on the expression of host cell genes are introduced, and the possible pathways of the miRNAs to the virus-mediated tumorigenesis are discussed.

关 键 词：MIRNAS 卡波氏肉瘤 肿瘤形成 

分 类 号：R3[医药卫生—基础医学]