银杏酮酯口服自微乳化给药系统的制备  

Preparation of the oral self-microemulsifying drug delivery system of GBE50

作　　者：熊颖[1,2] 刘启德[3] 赖乐[1] 陈建海[1] 

机构地区：[1]南方医科大学南方医院,广东广州510515 [2]广州中医药大学附属骨伤科医院,广东广州510240 [3]广州中医药大学,广东广州510006

出　　处：《药学学报》2009年第7期803-808,共6页Acta Pharmaceutica Sinica

摘　　要：研究制备银杏酮酯口服自微乳化给药系统。采用平衡溶解度方法筛选乳化剂与助乳化剂;采用伪三元相图法制备微乳;采用正交法优化处方组成;并考察自微乳化制剂的乳化效率、溶出度、稳定性与药动学研究等。结果表明,由肉豆蔻酸异丙酯IPM、聚氧乙烯蓖麻油Cremophor EL、丙二醇与银杏酮酯组成的自微乳化给药系统遇水可自发形成粒径为20～50 nm的稳定微乳。自微乳化给药系统的乳化效率与溶出快,且制剂稳定性高,能提高生物利用度。制备的银杏酮酯口服自微乳化给药系统稳定有效。To prepare the oral self-microemulsifying drug delivery system （SMEDDS） of GBE50, balance solubility method was used to screen emulsifier and assistant emulsifier; a pseudo-temary phase diagram was used to prepare microemulsion; and orthogonal design was used to optimize formulation. Self-microemulsifying efficiency, dissolution, stability and pharmacokinetics of the preparation were studied. As a result, GBE50- SMEDDS of IPM, Cremophor EL, 1,2-propanediol and GBE50 could be self emulsified to form stable microemulsion with particle diameter between 20 and 50 nm when emulsifying with water. Its self-microemutsifying efficiency and dissolution are quick with good stability and it has a higher bioavailability than market existing agents Xingling particles. GBE50-SMEDDS is stable and effective.

关 键 词：银杏酮酯 自微乳化给药系统 制备工艺 生物利用度 

分 类 号：R943[医药卫生—药剂学]