接种3剂甲肝减毒活疫苗8年的免疫学效果  

The immunological effects of three doses of a live attenuated hepatitis A vaccine （ H2 strain） in 8 years

作　　者：刘怀风 张新江[2] 张建立[2] 郝志勇[2] 张志勇[2] 马景臣[2] 陈吉朝[2] 褚娟[2] 汪萱怡[3] 徐志一[3] 

机构地区：[1]河北省正定县中医院,050800 [2]正定县疾病预防控制中心 [3]复旦大学生命科学院

出　　处：《中华实验和临床病毒学杂志》2009年第3期180-181,共2页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的观察接种3剂甲肝减毒活疫苗8年抗体持久性，并与1针法进行了比较。方法对农村1～7岁HAV易感儿童110人，接种1剂甲型肝炎减毒活疫苗作为B组，选其中一个自然村的42名易感儿童作为A组，按O、2、6个月程序接种3剂疫苗，分别于免疫后1、2、6、7、8、12、24、36和96个月采集血清标本，检测抗-HAV总抗体。结果B组接种甲肝减毒活疫苗后2～3个月，抗．HAV阳转率和几何平均浓度（GMC）达到高峰，分别为92．2％和126．2mIU／ml，然后开始随时间下降。与之相比，按照0、2、6个月程序免疫的A组，抗体阳转率在第二针后即达100％，第三针后GMC达高峰，为2739mIU／ml，A组的近期免疫效果甚至优于灭活疫苗；36～96个月B组的抗一HAV阳转率和GMC分别为75％～71％和80～89mIU／ml；与之相比，A组36～96个月的抗．HAV阳转率和GMC分别为100％和918．2～480．6mIU／ml，显著高于B组。结论接种3剂甲肝减毒活疫苗近期、远期免疫效果均高于一针法，三针法加强免疫取得了良好的免疫学效果，抗体持久性和预防效果有待于进一步观察。Objective To observe the immunological effects of three doses of H2 strain live attenuated hepatitis A vaccine 8 years after the administration and to compare with that of one dose of the vaccine. Methods In a country area, 110 children of 1 to 7 years old susceptible to HAV were screened and administered with one dose of the vaccine, as group B; Group A were 42 children from one of the villages and administered with 3 doses of the vaccine according to 0, 2, 6 month schedule. Blood samples were taken for the children 1, 2, 6, 7, 8, 12, 24, 36 and 96 months after the administrations respectively and detected for anti-HAV antibody. Results For group B, the sero conversion rate of anti-HAV and GMC reached peak at 92.2 % and 126.2 mIU/ml respectively, and then, began to drop with time; For group A, after 2 dose of the vaccine, the sero-conversion rate reached 100%, and the GMC reached peak of 2 739 mIU/ml one month after the third dose at 7 months. So that, group A has a better short-term immunological effects than that of group B. During 36 through 96 months, the anti-HAV positive rate in group B was 75%--71% and 80--89 mIU/ml respectively, and comparatively in group A were 100% and 918.2-480.6 mIU/ml respectively. The differences between group A and B were significantly important. Conclusion A 3-dose schedule administration of H2 strain live attenuated hepatitis A vaccine has better immunological effects than 1-dose schedule in 8years and further observations are needed.

关 键 词：肝炎病毒 甲型 疫苗 减毒 免疫接种 加强 免疫活性 

分 类 号：R186[医药卫生—流行病学]