高频超声评价胆红素水平对血管内皮功能的影响  

High resolution ultrasonography in evaluation of influence of serum bilirubin on endothelium-dependent dilation of artery

作　　者：刘艳[1] 张秀伦[2] 孙洋[1] 李秀昌[1] 

机构地区：[1]泰山医学院附属医院心内科,山东泰安271000 [2]泰山医学院诊断学教研室,山东泰安271000

出　　处：《中国医学影像技术》2009年第6期1036-1039,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨血清胆红素对内皮依赖性血管舒张功能的影响。方法随机选择100例心血管疾病患者分为三组:冠心病组31例、高血压组28例、冠心病合并高血压组41例;37名健康人作为对照组。应用高分辨力超声检测肱动脉血流介导性血管舒张功能(FMD)。采用全自动生化分析仪测定血清胆红素水平。结果心血管疾病患者血清总胆红素(TBIL)、间接胆红素(IBIL)、FMD和反应性充血的血流量变化率显著低于正常对照组。TBIL、IBIL与FMD、反应性充血的血流量变化率间呈显著正相关。多元逐步回归分析表明,除年龄、吸烟、收缩压、舒张压、脉压、血脂和血糖等影响因素外,TBIL进入回归方程。结论血清胆红素浓度越低,血管舒张功能越低;血清总胆红素是影响内皮依赖性血管舒张功能的独立危险因素。Objective To explore the effects of serum bilirubin on endothelium-dependent dilation of artery. Methods One hundred patients with cardiovascular diseases were included and divided into 3 groups： coronary heart disease group （n= 31）, hypertension group （n=28）, coronary heart disease combined with hypertension group （n=41）, and 37 normal volunteers were enrolled as control group. Flow-mediated dilation of humeral artery was measured by high resolution ultrasonography with GE VIVID 7 system. Serum bilirubin levels were measured by automatic chemical analyzer. Results In cardiovascular diseases group, flow-mediated dilation and the changes of blood flow during the reactive hyperaemia stage were significantly lower than those in control group, while total and indirect serum bilirubin correlated positively with FMD and the changes of blood flow during the reactive hyperaemia stage. Multi-variable stepwise regression indicated that the correlation was independent of other conventional risk factors such as age, smoking, systolic and diastolic blood pressure, pulse pressure, and so on. Conelusion The FMD and the changes of blood flow during the reactive hyperaemia stage correlate negatively and significantly with serum total and indirect bilirubin. The level of total serum bilirubin is an independent risk factor of the endothelium-dependent dilation function.

关 键 词：超声检查 胆红素 内皮 血管 

分 类 号：R445.1[医药卫生—影像医学与核医学] R331.32[医药卫生—诊断学]