Chemical constituents isolated from Saruma henryi  

马蹄香的化学成分研究(英文)

作　　者：董诗文[1] 尚明英[1] 王璇[2] 张树祥[1] 李晨[1] 蔡少青[1] 

机构地区：[1]北京大学药学院天然药物学系,北京100191 [2]北京大学药学院化学生物学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2009年第2期146-150,共5页中国药学（英文版）

基　　金：National Natural Science Foundation of China (Grant No. 30371748);the 985 Project of Peking University and the National Eleventh Five-year Key Technologies R & D Program of China (Grant No. 2006BAI14B01)

摘　　要：Chemical constituents of the whole herb of Saruma henryi Oliv. were investigated. The herbal extract was separated by repeated column chromatography over silica gel and celite. The structures were elucidated by spectroscopic analysis. Thirteen compounds were obtained and identified as 7-methoxyl-aristololactam Ⅳ （1）, aristololactam Ⅱ （2）, aristolochic acid Ⅰ （3）, aristololactam AⅡ （4）, daucosterol （5）, aristololactam Ⅰa （6）, N-trans-feruloyl tyramine （7）, aristololactam Ⅰ （8）, 4β,10β-aromadendranediol （9）, aristololide （10）, aristolic acid Ⅰ （11）, meso-dihydroguaiaretic acid （12）, and calopiptin （13）. These compounds were obtained from the genus Saruma for the first time, and they provided chemical evidences for the chemotaxonomy of plants of the Aristolochiaceae family. Since aristolochic acids and aristololactams are toxic to kidney, the results of this investigation suggest that it should be cautious to use Saruma henryi as a medicine.研究马蹄香Saruma henryi Oliv.全草的化学成分。利用溶剂萃取,反复硅胶、硅藻土色谱等手段进行分离纯化,根据理化性质、谱学数据进行结构鉴定。分离并鉴定了13个化合物,分别为7-甲氧基-马兜铃内酰胺IV(1)、马兜铃内酰胺II(2)、马兜铃酸I(3)、马兜铃内酰胺AII(4)、胡萝卜苷(5)、马兜铃内酰胺Ia(6)、穆坪马兜铃酰胺(7)、马兜铃内酰胺I(8)、4β,10β-香兰木二醇(9)、马兜铃内酯(10)、马兜铃次酸I(11)、内消旋二氢愈疮木酸(12)、calopiptin(13)。所有化合物均为首次从马蹄香属植物中分离得到。马兜铃酸和马兜铃内酰胺类成分具肾毒性,本研究提示马蹄香药用的安全问题值得关注研究结果亦为马兜铃科的化学分类学提供了依据。

关 键 词：ARISTOLOCHIACEAE Saruma henryi Chemical constituents Aristolochic acid ARISTOLOLACTAM 

分 类 号：R284.2[医药卫生—中药学]