2-(2-(4,6-二甲氧基嘧啶-2-氧)苯基)-4,4-二甲基异噁唑-3-酮的合成  

Synthesis of 2-(2-(4,6-Dimethyloxypyrimidine-2-oxy))-4,4-dimethylisoxazol-3-one

作　　者：潘彤[1] 黄朋勉[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410004

出　　处：《精细化工中间体》2009年第3期25-27,共3页Fine Chemical Intermediates

基　　金：湖南省科技攻关项目(2007FJ3052)

摘　　要：以邻甲酚、醋酸酐、4,4-二甲基异噁唑-3-酮、4,6-二甲氧基-2-甲磺酰基嘧啶为原料,经乙酰化、溴化、N-烷基化、醚化4步反应合成了标题化合物2-(2-(4,6-二甲氧基嘧啶-2-氧)苯基)-4,4-二甲基异噁唑-3-酮,收率42.4%,化合物结构采用1HNMR、IR、元素分析表征。The title compound 2-（2-（4,6-dimethyloxypyrimidine-2-oxy））- 4,4-dimethylisoxazol-3-one was synthesized in an overall yield of 42.4% in four reaction steps including acylation, bromination, N-methylation, and aetheration using o-methylphenol, acetic anhydri~ 4,4-dimethylisoxazol-3-one and 4,6-dimethyloxy-2- （methylsulfonyl） pyrimidine as the starting materials. The structure of the product was identified by using ^1H NMR, IR and element analysis.

关 键 词：嘧啶氧苄胺 异噁唑酮 合成 

分 类 号：Q621[生物学—生物物理学]