青春期肥胖儿童血清瘦素与胰岛素关系  

Relationship Between Serum Leptin and Serum Insulin in Obese Adolescents

作　　者：陈新岭[1,2] 王会贞[1] 张红 陈姜[1] 胡巧云[1] 娄晓民[1] 

机构地区：[1]郑州大学公共卫生学院,河南450001 [2]焦作卫生学校预防医学教研室 [3]新乡市第十中学校医室

出　　处：《中国学校卫生》2009年第6期547-548,共2页Chinese Journal of School Health

基　　金：河南省教育厅自然科学研究项目(编号:2006320028)

摘　　要：目的探讨青春期肥胖儿童血清瘦素(LEP)与空腹血清胰岛素(INS)的关系,为有效开展儿童肥胖防治工作提供参考。方法选取73对13～14岁青春期肥胖儿童和体重正常儿童为研究对象,测量身高、体重,并计算体质量指数(BMI),用放射免疫法测定空腹血清LEP和INS。结果青春期肥胖组男、女儿童平均血清LEP(20.35±6.88和28.21±3.65μg/L)均高于对照组(8.10±4.28和17.64±4.78μg/L),且男童LEP低于女童(P<0.01);肥胖组男、女儿童平均血清INS(29.40±14.08和25.20±11.72mIU/L)均高于对照组(17.23±7.13和16.85±5.08mIU/L),但未发现性别间差异(P>0.05)。在控制BMI后,LEP与INS在肥胖组和对照组男童中均存在正相关关系(P<0.05),在女童中均未发现相关性(P>0.05)。结论青春期肥胖儿童存在瘦素抵抗和胰岛素抵抗。肥胖儿童血清LEP女童高于男童,血清INS无性别差异。LEP与INS的相关性存在性别差异。Objective To examine the relation between fasting serum leptin （LEP） and fasting serum insulin （ INS ） in obesity adolescents, and to provide reference for children g obese prevention. Methods 73 pairs of obese and normal weight adolescents were recruited. Height, weight, fasting serum LEP and INS were measured. BMI was calculated. Results The average levels of serum LEP in male （ 20.35 ± 6.88 μg/L） and female（ 28.21 ±3.65 μg/L） in obese groups were higher than those in control groups （8.10 ±4.28 μg/L for male, 17.64 ±4.78μg/L for female ） , and serum LEP levels in male groups were lower than that in female groups（ P 〈0.01 ）. The average levels of INS in male and female（ 29.40 ±14.08 and 25.20 ±11.72 mIU/L） in obese groups were higher than that in control groups （ 17.23 ±7.13 and 16.85 ±5.08 mIU/L ） , and serum INS levels showed no difference between male groups and female groups（ P 〉0.05 ）. After controlling BMI, LEP and INS indicated positive correlation in male both in obese and control groups, but not in female groups. Conclusion There are leptin resistance and insulin resistance in obese adolescents; the level of serum leptin is relative with sex, but serum insulin doesn＇t show sexual difference. No gender differences exist in correlation between serum leptin and serum INS in male.

关 键 词：瘦素 胰岛素 血液化学分析 肥胖症 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R339.35[医药卫生—公共卫生与预防医学]