吡喹酮脂质体的制备及包封率测定  

THE MANUFACTURING METHOD AND DETER MINATION OF THE CLOSED RATE OF PRAZIQUANTEL LIPOSOME

作　　者：刘湘新[1] 肖洪波[1] 孙志良[1] 

机构地区：[1]湖南农业大学动物科学技术学院

出　　处：《湖南农业大学学报（自然科学版）》1998年第3期251-253,共3页Journal of Hunan Agricultural University(Natural Sciences)

基　　金：世界银行贷款项目

摘　　要：为了解吡喹酮脂质体的包封率及其稳定性，以便为兽医临床使用该制剂提供依据，采用逆向蒸发法制备了粒径为６～１０ｎｍ的吡喹酮小单层脂质体，并获得了６０％以上的药物包封率，灭菌后脂质体在４℃冰箱中保存，贮存６０ｄ。We have studied the closed rate and steadiness of praziquantel liposome by means of REV so that we can provide basis for the use of the drug at veterinary clinics. We′ve made the single layer praziquantel liposome diameter about 6~10 nm by means of REV. The closed rate reaches over 60%. When praziquantel liposome killed by bacteria is placed in the refrigerator for 60 days,its closed rate is on the whole steady.

关 键 词：吡喹酮 脂质体 制备 包封率 

分 类 号：TQ463.5[化学工程—制药化工] TQ460.69