褪黑素的合成研究  

A Study on Synthesis of Melatonin

作　　者：蔡晓宏[1] 刘鸿[1] 赵晏[2] 

机构地区：[1]西安近代化学研究所 [2]西安医科大学神经生物学研究中心

出　　处：《陕西化工》1998年第2期25-26,30,共3页Applied Chemical Industry

摘　　要：通过对褪黑素合成工艺的研究与改进，使氮的烷基化反应中的二溴丙烷消耗降低了３７％；关环反应中１０％氯化氢的乙醇溶液用量减少了３５％；５－甲氧基色胺精制中避免了高成本六甲基二硅胺的使用；乙酰化反应与产品的精制在同一体系中进行，这样既得到了高纯度褪黑素，又简化了工艺操作。使原料总成本降低达２５％左右，生产工艺更适合于工业化生产。产品达到药用标准。Through researching and improving of synthesis technology of melatonin, the consumption of 1,3-dibrompropane has been reduced by 37% in N-alkylation reaction, and the consumption of a 10% solution of gasous HCl in ethanol has been decreased by 35% in criclization reaction. It avoids using high cost hexamethyldisilazeme in refining 5-methoxy tryptamine. Acetylation reaction and refining melatonin used in the same system have not only obtained a high purity melatonin, but also simplified the working process. As a result, the total cost of the raw meterials has been reduced by about 25%, and the production technology more favours industrial production. The product has reached medicinal standards.

关 键 词：褪黑素 乙酰基 甲氧基色胺 合成 吲哚胺 激素 

分 类 号：TQ467[化学工程—制药化工] R977.1[医药卫生—药品]