驱动蛋白及其轨道的相互作用  

Study on the Microtubule-induced Kinesin Interaction Potential

作　　者：张红卫[1] 

机构地区：[1]郑州师范高等专科学校物理系,河南郑州450044

出　　处：《吉林师范大学学报（自然科学版）》2009年第2期38-41,共4页Journal of Jilin Normal University:Natural Science Edition

基　　金：河南省教育厅自然科学研究计划项目(2006140015);河南省科技发展计划项目(092300410142)

摘　　要：在驱动蛋白及其轨道物质结构的基础上,介绍了两者间相互作用的经验势模型,不对称周期势间的随机跃迁对自由扩散的整流导致了马达蛋白的定向运动;考虑马达及轨道的作用可能是电性的,电偶极子模型写出了内部偶极子和轨道偶极子间的作用势;基于分子动力学模拟以及单分子实验,静电模型利用Debye-Hückel理论,表明驱动蛋白的定向运动是依赖于ATP水解循环马达电荷分布与轨道偶极子相互作用的直接结果.Based on their structural properties, the article summarized the interaction potentials of kinesin and microtubule. The mechanical ratchet model that switched stochastically between different asymmetric, periodical potentials induced the motors＇ directional motion. After the discussion of electric dipoles interaction which was relatively realistic, we introduced the electrostatic model, in which the time varying charge distribution furnished by the ATP hydrolysis circle, and the static charge configuration on the micmtubule enabled the processivity and directionality.

关 键 词：驱动蛋白 微管 势 棘轮模型 电偶极子 静电模型 

分 类 号：O552.1[理学—热学与物质分子运动论]