聚富马酸丙二醇酯/(硫酸钙/β-磷酸三钙)生物复合材料的体外降解研究  

Study on the in vitro degradation of poly(propylene fumarate)/(calcium sulfate/β-tricalcium phosphate) biocomposites

作　　者：邸利芝[1] 刘斌[1] 罗跃娥[1] 赵红[1] 蔡仲雨[2] 

机构地区：[1]天津医学高等专科学校,天津300222 [2]天津大学材料科学与工程学院,天津300072

出　　处：《天津理工大学学报》2009年第3期56-60,共5页Journal of Tianjin University of Technology

基　　金：天津市教委科研计划项目(20071212);天津市科委基础研究重点项目(043803511)

摘　　要：研究了聚富马酸丙二醇酯／（硫酸钙β-磷酸三钙）（PPF／（CaSO4/β-TCP））生物复合材料降解过程中，PPF分子量、N-乙烯基吡咯烷酮（NVP）与PPF比例和CaSO。与β-TCP摩尔比对复合材料失重、吸水率、溶胀度、抗压强度和模量的影响．复合材料的失重、吸水率和溶胀度随着PPF分子量的增加或NVP／PPF比例、CaSO4／β-TCP摩尔比的降低而降低．降解前后的压缩强度和压缩模量随着NVP／PPF比例和CaSO4/β-TCP摩尔比的降低而升高．降解42d后，最大失重、吸水率和溶胀度分别达14．7％、57．O％和36．3％；通过42d的降解，所有试样的抗压模量在57．0～712MPa，最大抗压强度在3．1～20．6MPa，屈服强度在0．15～34．0MPa．通过SEM分析，观察到了PPF／（CaSO4/β-TCP）复合材料的原位成孔现象．The effects of varying poly （ propylene fumarate） （PPF） molecular weight, N-vinyl pyrrolidinone （NVP） to PPF ratio and CaSO4/β--TCP molar ratio on the weight loss, water absorption, swelling degree, compressive strength and modulus were examined during in vitro degradation of PPF/（CaSO4/β--TCP） composites. The weight loss,water absorption and swelling degree decreased with the increase of PPF molecular weight, or decrease of the NVP/PPF ratio and CaSO4/β--TCP molar ratio. The compressive strength and modulus increased with the decrease of the NVP/PPF ratio and CaSO4/β--TCP ratio. The greatest weight loss, water absorption and swelling degree over 6 weeks, were 14.72± 0.41%, 57.00± 0.92% ,36.30 ± 0.38% respectively. For all formulations, the compressive modulus values fell between 57.0 ± 38.3 to 712.0 ±284.8 MPa,the compressive strength fell between 3.1 ±2.0 to 20.6 ± 2.9 MPa and the yield strength ranged from 0.15 ±0.07 to 34.0 ±15.3 MPa throughout 6 week＇ s degradation. The SEM of the composites demonstrated the occurrence of in situ pores forming.

关 键 词：聚富马酸丙二醇酯 硫酸钙β-磷酸三钙 原位成孔 体外降解 

分 类 号：O632[理学—高分子化学]