国产雷帕霉素药物洗脱支架治疗冠心病患者的一年随访结果  

Clinical Follow-up Outcome of Firebird Stent for Treating Patients with Coronary Heart Disease for One Year

作　　者：刘国英[1] 胡硕强[1] 肖月[1] 王文斌[1] 梁峰[1] 胡大一[2] 吴明营[3] 李田昌[3] 汤楚中[2] 王吉云[3] 卢长林[3] 

机构地区：[1]首都医科大学大兴医院心内科,北京102600 [2]北京大学人民医院心脏中心,北京100044 [3]首都医科大学附属北京同仁医院心脏中心,北京100730

出　　处：《中国医药导刊》2009年第5期735-738,共4页Chinese Journal of Medicinal Guide

摘　　要：目的:本文观察火鸟支架(Firebird Stent,国产雷帕霉素药物洗脱支架)对冠心病患者治疗的一年临床随访结果,并与心扉支架(Cypher select stent)对比。方法:症状发作的冠心病患者,结合冠状动脉造影结果需行冠脉介入治疗,并分别置入火鸟支架或Cypher支架的原发冠状动脉病变,进行连续入选。冠状动脉介入治疗按常规进行,支架置入后均双联抗血小板治疗至少一年。对完全血管重建患者进行住院期间、6个月及一年临床随访。随访指标包括:死亡、心肌梗死、心绞痛复发,主要心脏不良事件(包括心源性死亡、心肌梗死、心绞痛发作、心力衰竭、再次血运重建、恶性心律失常等),以及支架血栓。与心扉支架对比,观察国产雷帕霉素洗脱支架的疗效和安全性。结果:2006年4月至2007年7月期间入选155例患者。其中完全血管重建107例,火鸟完全重建组48例,Cypher完全重建组59例。两组患者基线临床特征、所有冠状动脉造影及介入治疗过程特征均无显著性差异。住院期间、6个月、12个月临床随访结果显示,死亡率、心肌梗死、心绞痛复发,主要心脏不良事件,以及支架血栓发生率均无统计学显著差异。结论:根据住院期间、6个月及12个月临床随访结果显示,国产雷帕霉素药物洗脱支架治疗冠心病可取得与进口雷帕霉素药物洗脱支架同样的疗效和安全性,但需扩大样本数长期随访进一步研究。Objective：This study was to evaluate one year clinical follow-up efficacy and safety after Firebird stent implantation for patients with coronary heart disease（CHD） compared with Cypher select stent. Methods：One hundred and fifty five consecutive patients （ mean age 58. 93 ± 10.27 ）with coronary heart disease （CHD）, who underwent CAG and were implanted with Firebird stent or Cypher select stent at daxing hospital from April 2006 through July 2007 ,were enrolled. Before discharge and at six months and one year, patients with complete revascularization （no ≥50% stenosis in any coronary vessels after Stenting） were followed up for all-cause mortality,myocardial infarction,recurrence of angina pectoris, the major adverse cardiac events（ MACE,including cardiac death, myocrdial infarction, recurrence of angina pectoris, heart failure,revascularization, adverse arrhythmia）and Stent thrombosis,to compare the efficacy and safety of Firebird stent with Cypher select stent. Results： In the one hundred and fifty five COnsecutive patients,one hundred and seven patients were revascularized completely. Of these complete revaseularization patients,48 patients（ with 59 lesions）were treated with Firebird stent,59 patients（ with 75 lesions）were treated with Cypher select stent. The demographic characteristics were similar in the two groups. All the angiographic and procedural results were not significantly different between the two groups. Clinical follow-up was carried out in the two groups. All-cause mortality,myocardial infarction ,recurrence of angina peetoris,MACE and stent thrombosis were almost identical between the two groups before discharge, at six months and one year follow up. Conclusion： The efficacy and safety of Firebird stent for patients with Coronary heart disease, who were revascularized Completely, were similar to that of the Cypher select stent in term of in-hospital, six months and One year follow-up results, but further larger studies and longer follow-up are rewired to

关 键 词：冠心病 雷帕霉素药物洗脱支架 经皮冠状动脉内介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]