抗中性粒细胞胞浆抗体在溃疡性结肠炎的检测意义  

The Significance of Detection of Anti-neutrophil Cytoplasmic Antibodies in Ulcerative Colitis

作　　者：韩晓芳[1] 呼德[2] 王虹[1] 李慧君[1] 杜英[1] 

机构地区：[1]内蒙古自治区医院检验科,内蒙古呼和浩特010017 [2]内蒙古师范大学医院,内蒙古呼和浩特010022

出　　处：《内蒙古医学杂志》2009年第5期519-521,共3页Inner Mongolia Medical Journal

基　　金：内蒙古科技攻关项目(20070501)

摘　　要：目的:为探讨抗中性粒细胞胞浆抗体(ANCA)对溃疡性结肠炎(UC)的诊断意义。方法:采用间接免疫荧光法(IIF)检测53例UC、60例对照组(其中20例肠结核、40例健康体检者)血清中ANCA阳性率。结果:53例UC患者中,ANCA阳性39例,敏感性73.6%,特异性98.3%。对照组中20例肠结核患者血清中ANCA均阴性,40例健康体检者有1例ANCA阳性。结论:ANCA对UC的诊断特异性强,检查方便、无痛苦。可作为UC诊断的一项血清学指标,同时具有重要的鉴别诊断价值。Objective： To explore in the significance of anti- neutrophil cytoplasmic antibodies（ANCA） in the diagnosis of ulcerative colitis（UC）. Methods：The indirect immunofluorescence technique was used to detect the positive rate of serum ANCA in 53 eases of UC and 60 controls including 20 cases of intestinal tubeculosis and 40 healthy controls. Results： Of 53 cases of UC, 39 cases was positive in ANCA, the sensitivity was 73.6%, the specificity was 98.3%. In control group, the serum ANCA was positive in 20 cases of intestinal tubeculosis and 1 healthy one. Conclusion： ANCA is specific for diagnosis of UC, the technique is simple, feasible without trauma. It may be a indictor in diagnosis and differential diagnosis of UC.

关 键 词：抗中性粒细胞胞浆抗体(ANCA) 溃疡性结肠炎(UC) 间接免疫荧光法(IIF) 

分 类 号：R446.61[医药卫生—诊断学]