近年来吡虫啉合成新进展  

The New Improvement of Imidacloprid Synthesize in Recent Years

作　　者：程志明 

机构地区：[1]上海生农生化制品有限公司,上海201100

出　　处：《农药》2009年第7期469-470,486,共3页Agrochemicals

摘　　要：叙述了2000年以来2-氯-5-氯甲基吡啶和吡虫啉的多种合成方法。2-氯-5-氯甲基吡啶的合成采用环戊二烯环合法,需研发有利于环境的绿色生产工艺,减少三废,治理三废。以3-甲基吡啶为原料一步氯化成2-氯-5-氯甲基吡啶的工艺应进一步改进。吡虫啉合成中用五氧化二磷脱水法和过量2-硝基亚氨基咪唑烷法收率接近90%,纯度达95%以上,是较佳的合成方法。The synthesis methods of 2-chloro-5-chlormethylpyridine and imidacloprid from 2 000 were reviewed. The process of preparation for 2-chloro-5-chlormethylpyridine by cyclopentadiene cyclization needs to do more research by using green process and decreasing the wastes. The process of 2-chloro-5-chlormethylpyridine from 3-methylpyridine in one-step chlorination should be further improved. During the process of imidacloprid preparation, using phosphorus pentachloride dehydration and greatly excess 2-nitroiminoimidazolidine, the yield may reach 90%, and the purity is over 95%, so this a fairly good synthesis method.

关 键 词：吡虫啉 2-氯-5-氯甲基吡啶 合成 

分 类 号：TQ453.2[化学工程—农药化工]