2-乙酰肼基苯甲酰甲酸乙酯的合成  

Synthesis of Phenylglyoxylic Acid Ethyl Ester 2-Acetylhydrazones

作　　者：丁成荣[1] 张翼[1] 谢思泽[1] 贺孝啸[1] 周瑛[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032

出　　处：《农药》2009年第7期479-480,共2页Agrochemicals

摘　　要：苯甲酰腈在酸酐类催化剂作用下,经水解、酯化得到苯甲酰甲酸乙酯,然后在对甲苯磺酸催化作用下,与乙酰肼反应得到2-乙酰肼基苯甲酰甲酸乙酯,反应总收率为76.09%(以苯甲酰腈计),含量为99.34%,其结构经红外和核磁氢谱分析确证。Phenylglyoxylic acid ethyl ester was got via hydrolysis and esterification from berLzoyl nitrile in existence of anhydride. Then it was reacted with acetylhydrazine to synthesize phenylglyoxylic acid methyl ester 2-acetylhydrazones in existence of p-toluenesulfonic acid. Finally, its yield （base on benzoyl nitrile） was 76.09%, the purity was 99.34 %, and the structure was confirmed by IR and ^1H NMR.

关 键 词：苯甲酰腈 2-乙酰肼基苯甲酰甲酸乙酯 合成 

分 类 号：TQ245.24[化学工程—有机化工]