地诺前列酮联合地西泮用于足月妊娠引产的临床观察  

Clinical observation of prostaglandin E_2 combine Diazepam to artificial labor of pregnancy at term

作　　者：黄冬梅[1] 袁红霞[1] 张晓静[1] 李倩[1] 

机构地区：[1]广州中医药大学附属南海妇产儿童医院,广东佛山528200

出　　处：《中国实用妇科与产科杂志》2009年第7期517-519,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨地诺前列酮联合地西泮应用于足月妊娠引产的有效性及安全性。方法将南海妇产儿童医院2005年10月至2007年10月116例初产妇随机分为两组(各58例):研究组予地诺前列酮栓阴道用药配合地西泮静推,对照组仅予地诺前列酮栓阴道用药。比较两组用药后宫颈成熟度、引产效果、阴道分娩率、总产程时间、剖宫产率、子宫过度刺激发生率、胎心率变化、产后24h出血量及新生儿窒息率等指标。结果用药12h两组宫颈成熟度、引产成功率、胎儿窘迫发生率、产后出血量及新生儿窒息发生率差异无统计学意义(P>0.05);研究组子宫过度刺激发生率、总产程、剖宫产率分别为0、(11.42±4.27)h及5.17%,对照组分别为10.34%、(13.79±3.64)、17.24%,差异均有统计学意义(P<0.05)。结论地诺前列酮联合地西泮应用于引产可加快总产程,减少子宫过度刺激的副反应,提高阴道分娩成功率。Objective To explore the efficacy and safety of Prostaglandin E2 and Diazepam combined usage for cervical ripening and intermediate labour induction. Method One hundred and sixteen women with uterogestation were divided into two groups randomly. Prostaglandin E2 was put into the vaginas of 58 women with uterogestation in control groups. In addition to putting Prostaglandin E2 into the vaginas of women, study group intravenous inject Diazepam. The cervical ripeness（ Bishop scoring）, condition of delivery, vaginal delivery rate, total stage of labor, excess stimulus of uterus, blood volume of postpartum, fetal and neonatal condition were studied. Results There is no significant difference of cer- vical ripeness, incidence rate of fetal distress, blood volume of postpartum and neonatal condition between study group and control group. The incidence rate of excess stimulus of uterus in study group is 0,that of control group is 10. 34% , the difference was significant（P 〈0. 05）. The average total stage of labor in study group is （ 11.42±4. 27） hours, that of control group is （ 13.79 -±3.64 ） hours, the difference was significant （ P 〈0. 05 ）. U - D rate of study group is 5. 17 %, U - D rate of control group is 17.24%, the difference was significant （ P 〈 0. 05 ）. Conclusion Prostaglandin E2 （PGE2） and Diazepam combined used for intermediate labour induction can shorten total stage of labor, reduce the incidence rate of excess stimulus of uterus, increase vaginal delivery rate.

关 键 词：地诺前列酮 地西泮 引产 

分 类 号：R71[医药卫生—妇产科学]