衔接蛋白p66Shc在糖尿病及其并发症中的作用  

Role of adaptor protein p66Shc in diabetes and its complication

作　　者：聂静[1] 孙林[1] 刘伏友[1] 

机构地区：[1]中南大学湘雅二医院肾脏病研究所,长沙410011

出　　处：《国际病理科学与临床杂志》2009年第3期250-253,共4页Journal of International Pathology and Clinical Medicine

摘　　要：p66Shc是调控氧化应激和生命周期的关键蛋白。在氧化应激信号的刺激下,p66Shc在线粒体内氧化细胞色素C产生大量活性氧,造成细胞的氧化损伤。最新的研究表明,p66Shc可能在衰老及衰老相关的疾病如糖尿病中扮演关键的角色。本文简要综述p66Shc的结构、功能、相关的信号通路及其在糖尿病领域的最新研究进展。The p66Shc adaptor protein controls cellular oxidative stress responses and life span. It oxidizes cytochrome C and generates reactive oxygen species （ROS） within mitochondria in response to oxidative stress. Recently, there is growing evidence suggests that p66Shc is involved in aging and aging- related disease, such as diabetes mellitus. The present review will focus on our current knowledge of the structure and function of p66Shc, and its role in diabetes mellitus.

关 键 词：P66SHC 氧化应激 活性氧 糖尿病 

分 类 号：R587.2[医药卫生—内分泌]