转化生长因子β1基因509C/T单核苷酸多态性与子痫前期-子痫关系的探讨  

Study on single nucleotide polymorphism of the TGFβ1-509C/T in eclampsia/pre-eclampsia

作　　者：朱宇 廖志琼[2] 陈盛强[2] 

机构地区：[1]深圳市福永医院妇产科,深圳518103 [2]广州医学院第二附属医院妇产科

出　　处：《现代妇产科进展》2009年第7期537-540,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨转化生长因子β1(TGFβ1)基因509C/T单核苷酸多态性及其血清水平与子痫前期-子痫的关系。方法:用酶免法测定52例子痫前期-子痫患者及68例健康对照者血清TGFβ1水平,用聚合酶链反应扩增TGFβ1-509C/T基因片段,Eco81I内切酶进行限制性酶切反应并经测序证实。结果:52例子痫前期-子痫患者及68例正常对照TGFβ1-509C/T基因型及等位基因频率均无显著差异,而血浆中TGFβ1水平,子痫前期-子痫组明显高于对照组,两组差异有统计学意义(P<0.05)。结论:血清TGFβ1水平显著升高提示炎性反应在子痫前期-子痫病程中有重要作用,TGFβ1-509C/T基因多态性与子痫前期-子痫无关。Objective：To investigate the relationship between serum levels of TGFβ1 and its polymorphism and eclampsia/pre-eclampsia. Methods： Serum level of TGFβ1 was measured by ELISA,and the polymorphism of TGFβ1-509C/T gene was screened by PCR-RELP. Results： Eclampsia/pre-eclampsia group showed significantly higher serum level of TGFβ1 than the control group （ P 〈 0.05 ）. There was no significant difference between eclampsia/pre-ec- lampsia group and the control group for TGFβ1-509C/T polymorphism （P 〉 0.05 ）. Conclusion：Serum TGFI31 increases in eclampsia/pre-eclampsia and there is no association between TGFβ1-509C/T polymorphisms and eclampsia/pre-eclampsia.

关 键 词：子痫前期 子痫 转化生长因子Β1 多态性 单核苷酸 

分 类 号：R714.24[医药卫生—妇产科学]