单纯疱疹病毒感染与急性心肌梗死的相关性研究  

Relation between herpes simplex virus infection and acute myocardial infarction

作　　者：杨铭华[1] 关秀茹[1] 张萱[1] 杜柏岩[1] 韩丽[1] 杨志平[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院实验诊断教研室,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2009年第3期271-274,共4页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D200613);黑龙江省卫生厅科研课题(2006-058)

摘　　要：目的探讨单纯疱疹病毒(herpes simplex virus,HSV)感染与急性心肌梗死(acute myocardial infarction,AMI)之间的关系。方法采用ELISA方法检测72例AMI患者与79例正常对照组血清中HSV-1及HSV-2抗体水平,同时检测两组的白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平,并进行冠心病危险因素调查。结果AMI组HSV-1 IgG抗体阳性率(73.61%)、HSV-2 IgG抗体阳性率(58.33%)显著高于对照组(39.24%,36.71%;P<0.01,P<0.05)。AMI组IL-6(108.29)、TNF-α(37.82)水平与对照组(22.27,3.32)比较差异有统计学意义(P<0.01)。调整冠心病危险因素前后,HSV-1和HSV-2 IgG抗体阳性率均与AMI有相关性(HSV-1:OR=4.4,P=0.01;OR=4.8,P=0.001;OR=3.5,P=0.012。HSV-2:OR=2.2,P=0.001;OR=3.5,P=0.006;OR=3.3,P=0.009)。结论HSV感染可能通过激发和加重冠状动脉内炎症反应,参与动脉粥样硬化(atherosclerosis,AS)及AMI发生、发展的病理过程。Objective To study the correlation between herpes simplex virus （HSV） infection and aeute myocardial infarction （AMI）. Methods HSV-1 and HSV-2 IgG antibodies of 72 patients with AMI and 79 normal controls were measured by ELISA. The levels of interleukin-6 （IL-6） and tumor necrosis factor α（TNF-α） were also determined. Meanwhile, the risk factors of coronary heart disease were investigated. Results The positive rates of HSV-1 and HSV-2 IgG antibody（73.61% ,58.33% ） in AMI group were significantly higher than those in control （39.24%,36.71% ;P 〈0.01 ,P 〈0.05）. Before and after the adjustment of cardiovascular risk factors,IgG antibodies to HSV-1 and HSV-2 were both correlated with AMI（HSY-1：OR= 4.4,P=0.01：OR=4.8,P=0.001;OR=3.5,P=0.012. HSV-2：OR= 2.2,P= 0.001 ; OR = 2.9, P = 0. 006 ; OR = 3.3, P = 0. 009, respectively）. The coneentrations of IL-6 （ 108.29 ） and TNF-α （37.82）in the AMI group were all higher than those （22.27,3.32） in the control group （all P 〈0. 01）. Conclusion There is significant correlation between HSV infection and AMI. HSV infection may be involved in the pathogenesis of atherosclerosis and acute myocardial infarction by inducing and accelerating coronary artery inflammation.

关 键 词：单纯疱疹病毒 动脉粥样硬化 急性心肌梗死 细胞因子 

分 类 号：R542.22[医药卫生—心血管疾病]