相位加权成像在多系统萎缩与帕金森病的鉴别诊断中的作用  

Phase-weighted Imaging in Differentiating Multiple System Atrophy from Idiopathic Parkinson Disease

作　　者：冯逢[1] 有慧[1] 王含[2] 郑福玲[1] 金征宇[1] 崔丽英[2] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院神经内科,北京100730

出　　处：《中国医学科学院学报》2009年第2期129-133,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(30670608);北京协和医院青年科研基金(0309102)~~

摘　　要：目的评价相位加权成像在多系统萎缩与帕金森病的鉴别诊断中的作用。方法对21例多系统萎缩、20例帕金森病患者及26例年龄匹配的正常对照者在3.0T磁共振成像系统上行常规头部磁共振成像后行相位加权成像,成像范围覆盖整个纹状体。在不知道患者临床诊断的情况下在后处理得到的相位图像上确定测量的感兴趣区并测量记录双侧壳核、苍白球及尾状核头的平均相位位移值。结果多系统萎缩患者双侧壳核的相位位移值显著低于帕金森病患者及正常对照者(P<0.05),其他各部位的相位位移值差异无显著性,帕金森病患者与正常对照者在各观察区域差异均无显著性。结论相位加权成像是一个评价运动障碍疾病脑内铁异常沉积的有价值的序列,定量评价铁沉积程度有助于更好地鉴别多系统萎缩与特发性帕金森病。Objective To assess the efficacy of phase-weighted imaging in differentiating multiple system atrophy （MSA） from idiopathic Parkinson disease （IPD）. Methods A phase-weighted sequence was performed covering striatum in 21 patients with MSA, 20 patients with IPD, and 26 age-matched healthy volunteers after conventional brain magnetic resonance imaging examination on a 3.0T magnetic resonance imaging system. An experienced neuroradiologist who were blind to the clinical diagnosis applied region of interest （ROI） on post-processing phase images to measure the phase shift value of bilateral globus pallidus, putamen, and caudate head. Results The phase shift values at bilateral putamen of MSA group were significantly lower than those of IPD group and control group （ P 〈 0.05 ）, while phase shift values at other locations of MSA group were not statistically different from those of other groups. The phase shift values showed no statistical difference between IPD group and control group at all regions. Conclusion Quantitative phase-weighted imaging is a useful sequence to reflect the abnormal iron accumulation in brains of patients with movement disorders and is helpful in the differential diagnosis between MSA and IPD.

关 键 词：多系统萎缩 帕金森病 相位加权成像 相位位移值 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]