正常肾脏皮质的64层螺旋CT灌注特征  

Perfusion Characteristics of Normal Renal Cortex with 64-slice Spiral CT

作　　者：孙昊[1] 薛华丹[1] 刘炜[1] 金征宇[1] 赵文敏[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730

出　　处：《中国医学科学院学报》2009年第2期232-236,I0012,共6页Acta Academiae Medicinae Sinicae

摘　　要：目的应用64层螺旋CT体部灌注成像技术研究正常肾脏皮质灌注特征,并探讨各灌注参数与性别、年龄及血清肌酐(Scr)的相关性。方法对71名无明显泌尿系统疾病的志愿者进行64层螺旋CT腹部平扫和灌注增强扫描,使用BodyPCT灌注软件测量正常肾脏皮质灌注参数,包括血流量(BF)、血容量(BV)和渗透性(PM),比较同一灌注参数在不同性别和年龄间的差异,探讨灌注参数与年龄、PM与Scr的相关性。结果3人灌注扫描失败,68人灌注扫描成功,共得到108人次的正常肾脏灌注参数,其中获得71人次CT灌注扫描前1周内的Scr值。男性正常肾脏皮质(n=56)的灌注参数测量结果为:BF=(229.8±49.9)ml/(100ml.min)、BV=(398.2±59.5)1000∶1、PM=(213.5±54.0)0.5ml/(100ml·min);女性正常肾脏皮质(n=52)的灌注参数测量结果为:BF=(230.0±56.1)ml/(100ml·min)、BV=(358.1±49.7)1000∶1、PM=(186.2±32.1)0.5ml/(100ml·min);全体正常肾脏皮质(n=108)的灌注参数测量结果为:BF=(229.9±52.7)ml/(100ml·min)、BV=(378.9±58.4)1000∶1、PM=(200.4±46.7)0.5ml/(100ml·min)。BF(F=0.367,P=0.547)、BV(F=3.088,P=2.762)和PM(F=3.308,P=0.074)在性别间差异无显著性(P>0.05)。在男、女性和全体受试者中,BF与年龄具有一元线性相关关系(r=-0.484,r=-0.429,r=-0.425;均P<0.01),BV(r=-0.152,r=-0.243,r=-0.043)和PM(r=0.053,r=0.123,r=0.172)与年龄无相关关系(均P>0.05)。PM与Scr无相关关系(r=0.064,P>0.05)。结论采用64层螺旋CT灌注成像技术测量正常肾皮质灌注参数的方法切实可行,肾脏CT灌注成像可以定量评价肾脏皮质的生理功能特点。Objective To evaluate perfusion characteristics of normal renal cortex with 64-slice spiral CT and to investigate the correlation between perfusion parameters and gender, age, and serum creatinine （Ser）. Methods In total 71 healthy subjects, the kidney non-enhanced imaging and perfusion imaging with 64-slice spiral CT were performed. Perfusion parameters of renal cortex including blood flow （BF） , blood volume （BV）, and permeability （PM） were calculated with Siemens Body PCT （VB20B） software. The differences of BF, BV and PM in different age and gender people were compared by one-way ANOVA. The correlation between age and perfusion parameters, Scr, and PM were analyzed. Results Technical failures were experienced in 3 （3/71,4.2%） subjects. Perfusion Values of normal renal cortex in male, female, and all subjects were obtained separately. Male subjects （n =56） ： BF = （229.8 ±49.9） ml/（ 100 ml · min）, BV =（398.2±59.5） 1000：1, PM= （213.5±54.0） 0.5ml/ （100ml·min）; female subjects （n=52）： BF= （230.0±56.1） ml/ （100ml ·min）, BV= （358.1 ±49.7） 1000：1, PM= （186.2±32.1） 0.5 ml/ （ 100 ml · min） ; all subjects （n = 108） ： BF = （229.9 ± 52.7） mE/ （ 100 ml · min）, BV = （378.9 ± 58.4） 1 000：1, PM = （200. 4 ±46.7） 0. 5 ml/ （ 100 ml · min）. There was no significant difference in BF （F=0.367, P=0.547）, BV （F=3.088, P=2.762）, and PM （F=3.308, P=0.074） between male and female. In male, female, and all subjects, BF were all negatively correlated with age （ r = - 0. 484, r = -0.429, r= -0.425; P〈0. 01）, while there was no correlation between BV （r = -0.152, r = - 0.243, r=-0.043, P〉0. 05）and PM （r=0.053, r=0. 123, r=0. 172, P〉0.05）and age. There was no correlation between PM and Ser （ r = 0. 064, P 〉 0.05 ）. Conclusion The measurement of normal renal cortical perfusion characteristics with 64-slice spiral CT is feasible and can be used for the quantitative evaluation of the ph

关 键 词：肾皮质 CT 灌注成像 

分 类 号：R814.42[医药卫生—影像医学与核医学]