自组装多肽纳米纤维材料在神经组织工程中的应用  

APPLICATION OF SELF-ASSEMBLING PEPTIDE NANOFIBER SCAFFOLD IN NERVE TISSUE ENGINEERING

作　　者：王佰川[1] 邵增务[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院骨科,武汉430022

出　　处：《中国修复重建外科杂志》2009年第7期861-863,共3页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30500511)~~

摘　　要：目的综述自组装多肽纳米纤维材料(self-assembling peptide nanofiber scaffold,SAPNS)的基础研究及其在神经组织工程中的研究现状。方法广泛查阅近期国内外SAPNS研究的相关文献,并进行回顾和综合分析。结果SAPNS可促进神经干细胞的黏附、增殖和分化以及神经元轴突向外生长和延伸,促进ECM的合成并能抑制神经胶质细胞的黏附和分化,很好地模拟了细胞在体内的生长环境。结论SAPNS是一种理想的基质材料,为损伤神经组织的修复提供了新的方法。Objective To review the fundamental research and the experimental study in the nerve tissue engineering of self-assembling peptide nanofiber scaffold （SAPNS）. Methods The literature concerning basic and experimental studies on SAPNS in the nerve tissue engineering was extensively reviewed. Results SAPNS can promote the neural stem cell adhesion, proliferation, differentiation and neuron axon outward growth and extension, promote extracellular matrix synthesis and inhibit glial cell adhesion and differentiation, and simulate the environment of a cell in the body. Conclusion SAPNS is an ideal matrix material and provides a new way for the repair of nerve tissue injury.

关 键 词：神经组织工程 自组装多肽纳米纤维 神经干细胞 修复 

分 类 号：R318.08[医药卫生—生物医学工程] R745[医药卫生—基础医学]