地尔硫联合硝酸甘油对高龄三支病变心绞痛的疗效和安全性观察  

Study on efficacy and safety of diltiazem plus nitroglycerin for angina pectoris of older three-vessel disease

作　　者：夏经钢[1] 徐东[1] 

机构地区：[1]首都医科大学宣武医院心脏中心,北京100053

出　　处：《中国医院药学杂志》2009年第13期1101-1103,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察静脉应用地尔硫联合硝酸甘油对高龄患者冠脉三支病变导致不稳定性心绞痛的临床疗效和安全性,以促进其安全合理应用。方法:选择100例75～85岁冠脉三支病变所致不稳定性心绞痛患者,随机分为治疗组和对照组,每组各50例患者。治疗组在常规治疗基础上静脉给予地尔硫2μg·min-1·kg-1联合硝酸甘油0.1μg·min-1·kg-1,对照组在常规治疗基础上静脉给予硝酸甘油0.1μg·min-1·kg-1,两组均24h持续微量泵入,对两组患者的疗效和不良反应进行比较分析。结果:治疗组平均心绞痛发作次数显著减少,平均心绞痛最长时间显著缩短,室性恶性心律失常发生次数明显减少,心电图缺血性表现显著改善;但是相关不良反应有增多趋势。结论:静脉应用地尔硫联合硝酸甘油对高龄冠脉三支病变不稳定心绞痛疗效确切,但可能出现不良反应,应予以注意。OBJECTIVE To study efficacy and safety of diltiazem plus nitroglycerin for unstable angina pectoris of older three-vessel disease in order to benefit rational and safe use of diltiazem.METHODS 100 patients of seventy five to eighty five years old with unstable angina pectoris were treated randomly with diltiazem 2μg·min^-1·kg^-1 plus nitroglycerin 0. 1 μg·min^-1·kg^-1 and nitroglycerin 0. 1μg·min^-1·kg^-1 for 24 hours to observe efficacy and safety. RESULTS Compared with control group, there were significant improvements on efficacy,but there were more adverse reaction such as bradycardia, hypotension, headache, nausea, eruption and heart failure. CONCLUSION The clinical curative effect of diltiazem plus nitroglycerin for Older three-vessel disease unstable angina pectoris was available but care of adverse drug reaction should be taken.

关 键 词：地尔硫(艹卓) 硝酸甘油 不稳定心绞痛 三支病变 

分 类 号：R972[医药卫生—药品]