治疗用肉毒毒素A在面部除皱中的疗效观察  

Observation of curative effect of botulinum toxin A for treatment of facial wrinkles

作　　者：勾庆芬[1] 李芸[1] 钟文慧[1] 姚翠英[1] 田霞[1] 杨喆[1] 邵芳[1] 

机构地区：[1]武汉科技大学附属天佑医院整形美容科,湖北武汉430064

出　　处：《中国医院药学杂志》2009年第13期1111-1114,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨肉毒毒素A在面部除皱术中的维持时间、多次注射的远期疗效、不同部位的疗效差异及药物对其影响等。方法:用肉毒毒素A注射面部皱纹568例,其中490例仅进行额纹、鱼尾纹、眉间纹的注射,43例注射上述三部位加下睑皱纹,35例注射额纹、鱼尾纹、眉间纹加鼻唇沟纹;其中3例仅注射额纹、鱼尾纹、眉间纹及1例注射上述三部位加鼻唇沟纹的3mL注射液中加入了2%利多卡因0.2mL。568例受术者有204例进行了第2次注射,102例进行了第3次注射,35例进行了第4次注射。结果:首次注射疗效维持6～9个月者,额纹、鱼尾纹、眉间纹占65.96%,下睑纹占51.16%,鼻唇沟纹占23.53%。第1、2、3、4次注射维持时间呈递减趋势。注射液中加入利多卡因疗效明显减弱。结论:肉毒毒素A在面部除皱首次注射的维持时间多数在6～9个月之间;多次注射维持时间呈递减趋势;利多卡因可减弱药效。OBJECTIVE To explore the maintain time,long-term effect of multiple injections,effect difference at different location and drug interaction of using BTX A for treatment of facial wrinkles. METHODS BTX A injection was given for 568 subjects with brow wrinkles, fish tail wrinkles and glabellar wrinkles,in which BTX A injection was given in 43 cases with lower eyelid wrinkles,35 cases with nasolabial furrow wrinkle. 0. 2 mL lidocaine hydrochloride in the injection was given in 4 cases with brow striae,fish tail striae and glabella wrinkles,and in 1 case of nasolahial furrow wrinkle. Among them 204 cases were given with the second injection, 102 cases were given with the third injection,35 cases were given with the fourth injection. RESULTS The first injection effect maintained 6-9 months in 65. 96% of brow wrinkles, fish tail wrinkles and glabellar wrinkles, in 51.16% of lower eyelid wrinkles, 23. 53% of nasolabial furrow wrinkles. The decreasing tendency of maintaining time was shown from the first injection, the second injection, the third injection to the forth injection. The effect was reduced in adding lidocaine hydrochloride in the injection. CONCLUSION The maintaining time of first injection with BTX A for treatment of facial wrinkles is 6-9 months; the effect of multiple injections is decreasing; the effect is reduced with adding lidocaine hydrochloride in the injection.

关 键 词：肉毒毒素A 面部皱纹 疗效 

分 类 号：R969.3[医药卫生—药理学]