过敏性紫癜患儿尿中肝细胞生长因子检测及临床意义  

Urinary excretion of hepatocyte growth factor in Henoch-Schnlein purpura children and its clinical significance

作　　者：丁文捷[1] 孙书珍[1] 王延栋[1] 

机构地区：[1]山东大学附属省立医院儿科肾脏风湿免疫科,济南250021

出　　处：《中国实用儿科杂志》2009年第7期545-547,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的检测不伴或伴有不同程度白蛋白尿的过敏性紫癜(HSP)患儿尿中肝细胞生长因子(HGF)水平的变化,评价其临床意义。方法选择山东大学附属省立医院儿科2007年8月至2008年4月收治的急性期HSP患儿78例,按照尿白蛋白排泄率(UAER)分成正常白蛋白尿组(Ⅰ组,38例)、微量白蛋白尿组(Ⅱ组,24例)和大量白蛋白尿组(Ⅲ组,16例),采用双抗体夹心ELISA方法分别检测所有患儿急性期及其中部分患儿恢复期尿HGF,与26例健康对照儿童进行比较。结果与对照组相比,Ⅰ组和Ⅱ组尿HGF水平均升高,且呈递增趋势,差异有统计学意义(P<0.05);而Ⅲ组尿HGF水平与对照组相比差异无统计学意义(P>0.05);Ⅰ、Ⅱ组患儿恢复期尿HGF水平为1.22±0.67较其急性期1.85±1.15明显降低,差异有统计学意义(P<0.05);Ⅲ组患儿恢复期尿HGF水平为1.43±0.31较其急性期0.30±0.31显著升高,差异有统计学意义(P<0.01)。结论HGF参与紫癜性肾炎(HSPN)患儿肾脏损伤的修复,尿HGF水平的监测有助于评估HSPN的病情及预后,外源性HGF的介入可能成为早期干预、防治HSPN的有效方法。Objective To measure the levels of urinary hepatocyte growth factor（HGF） and evaluate its clinical significance in children with Henoeh-Schonlein purpura （HSP）. Methods A total of 78 children of HSP were divided into three groups according to urinary albumin excretion rate （UAER） ：normal albuminuria group：〈 20μg/min （group I, n = 38） ; microalbuminuria group： 20 - 200 μg/min （group Ⅱ , n = 24） ; macroalbuminuria group 〉 200μ g/min （group Ⅲ , n = 16 ） .The urinary HGF was determined by ELISA and compared with 26 healthy children （control）. Results In comparison with the control, urinary HGF was increased in normoalbuminuria and microalbuminuria patients respective- ly （HGF-to-creatinine ratio： control 0.73±0.50, normoalbuminuria 1.35±0.96, mieroalbuminuria 2.63±1.25; P 〈 0.05 and P 〈 0.01 for normoalbuminuria and microalbuminuria vs. control, respectively, P 〈 0.01 for normoalbuminuria vs. microalbuminuria）. No obvious difference was observed between maeroalbuminuria patients 0.40±0.34 and the controls （P 〉 0.05）. Urinary HGF significantly decreased in recovery phase compaired with acute phase 1.22±0.67 vs 1.85±1.15 （P 〈 0.05） in normoalbuminuria and microalbuminuria patients, but significantly increased in maeroalbuminuria patients 1.43±0.31 vs 0.30±0.31 （P 〈 0.01 ）. Conclusion Our findings suggest that HGF may contribute to the repair of renal injury in children with Henoch-Schonlein purpura nephritis （HSPN）. Exogenic HGF intervention may be effective in the prevention and treatment of HSPN.

关 键 词：肝细胞生长因子 过敏性紫癜 紫癜性肾炎 尿白蛋白排泄率 

分 类 号：R72[医药卫生—儿科]