深圳市HIV阳性人群HPV病毒载量分析  

HPV infection status and viral load in HIV positive people in Shenzhen city

作　　者：温贵华[1] 刘晋洪[1] 黄玲[1] 申杰[1] 刘婷[1] 郭夏娜[1] 翁琼琳[1] 邓文国 

机构地区：[1]深圳市宝安区慢性病防治院检验科,518133 [2]广州达安临床检验中心

出　　处：《中国公共卫生》2009年第7期795-796,共2页Chinese Journal of Public Health

摘　　要：目的了解深圳市人类免疫缺陷病毒(HIV)阳性及阴性人群中人乳头瘤病毒(HPV)感染情况。方法荧光定量PCR法检测HPV感染情况以及病毒载量。结果40例HIV阳性组中HPV阳性20例,感染率为50.0%,在HIV阴性组中HPV阳性7例,感染率为17.5%,差异有统计学意义(P<0.05);HIV阳性组HPV病毒载量比HIV阴性组至少高1个数量级(P<0.05);检出16种HPV亚型,其中包括11种高危型,5种低危型,感染率最高的为16型(5例),其次为52型(4例)、58型(3例)。结论HIV感染人群中HPV感染率、病毒载量较高,且多型感染情况较严重。Objective To research human papilloma virus （HPV） infection status in human immunodeficiency virus （HIV） positive people and in HIV negative people in Shenzhen city. Methods To detect HPV infection status and HPV virus load with fluorescence quantitative PCR. Results In 40 HIV positive persons, there were 20 HPV infections, and the infection rate was 50. 0%. In HIV negative persons,there were 7 HPV infections,and the infection rate was 17.5%. There was a significant difference（P 〈 0. 05）. The HPV load of HIV positive persons was significantly higher than that of HIV negative persons（P 〈0. 05）. There were 16 types of HPV variants including 11 with high-risk,5 with low risk. The infection rate was the highest for type-16（5 people） ,and type-52（4 people） ,third for type-58（3 people） ,respectively. Conclusion HPV infection rate among HIV positive people was significantly higher with heavy viral load and multi-type infection condition was serious.

关 键 词：人类免疫缺陷病毒(HIV) 人乳头瘤病毒(HPV) 病毒分型 病毒载量 

分 类 号：R512.91[医药卫生—内科学]