心理健康对生化指标影响及与HLA-DQB1关系  

Influences of mental health on biochemical indicators and correlations with HLA-DQB1

作　　者：李自越[1] 潘晓兰[1] 刘辉[1] 

机构地区：[1]大连医科大学检验医学院临床免疫学教研室,大连116044

出　　处：《中国公共卫生》2009年第7期825-826,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(30770724)

摘　　要：目的探讨心理健康状态的变化对血清生化指标的影响及其与人类白细胞抗原-DQB1(HLA-DQB1)等位基因的关系。方法在普通健康体检人群中采用症状自评量表(SCL-90)筛选心理健康异常者50人,并选取正常者37人作为对照,实验室检测其血清生化指标;HLA-DQB1*02、*03、*04、*05和*06位点分别应用聚合酶链反应(PCR)由第2外子显组特异性引物扩增得到,并分析其与血清生化各指标之间的关系。结果心理健康状态异常组与对照组比较,HLA-DQB1*02位点分布频率升高,差异有统计学意义(P<0.05)。心理健康状态异常组与对照组比较高密度脂蛋白(HDL)降低、低密度脂蛋白/高密度脂蛋白(LDL/HDL)升高,差异有统计学意义(P<0.05);HLA-DQB1*02、*03和*05*06位点分别与不同的血清生化指标变化有关,与对照组比较,差异有统计学意义(P<0.05),心理异常组白蛋白/球蛋白(A/G)、LDL/HDL升高,而HDL、血糖(GLU)降低。结论心理健康状态的改变可以引起血清生化某些指标的改变并与HLA-DQB1等位基因表型有关。Objective To explore the effect of mental health on serum biochemical indicators and the correlation with allelomorphic genes of HLA-DQB1. Methods Fifty people with abnormal mental health screened with SCL-90 and 37 normal people were selected as experimental group and control group from physical examinees. Biochemical indicators were detected with auto eqtfipmant. HLA-DQB1 ＊02, ＊03, ＊04,＊05 and ＊ 06 alleles were individually amplified by polymerase chain reaction（PCR） using exon 2 group-specific primers and the correlation with serum biochemical indicators was investigated. Results Statistical analysis showed significant difference in frequency distribution of HLA-DQB1 ~ 2 （P 〈 0. 5 ） between two groups. The high-density lipoprotein（HDL） in experimental group was significantly higher than that of in control group （P 〈 0. 5） ;while the LDL/HDL in experinental group was significantly lower than that of in control group （P 〈 0. 5 ）. There was a significant difference in the effect of serum biochemical indicators on the HLA-DQB1＊02,＊03 and ＊ 06 between the experimental group and control group （ P 〈 0. 5 ）. Compared with the control group, A/G and LDL/HDL were higher and HDL and blood glucose were lower in experimental group. Conclusion Different state of mental health could change some serum biochemical indicators and this was related with the phenotype of HLA-DQB1.

关 键 词：心理健康 症状自评量表(SCL-90) 临床生化 人类白细胞抗原 

分 类 号：R181.36[医药卫生—流行病学]