可吸入颗粒物对心血管系统急性效应的meta分析  

Acute Adverse Effect of Air Particulate Matter (PM_(10)) Pollution on Cardiovascular Diseases(CVD):a Meta-analysis

作　　者：王均琴[1] 柏建岭[1] 陈峰[1] 

机构地区：[1]南京医科大学流行病与卫生统计学系,210029

出　　处：《中国卫生统计》2009年第3期229-233,共5页Chinese Journal of Health Statistics

基　　金：973计划项目(2002CB512910)

摘　　要：目的系统评价可吸入颗粒物(PM10)对心血管系统急性有害效应的影响。方法检索PubMed、CBM、CNKI等数据库,同时手工检索相关杂志和参考文献,选择符合标准的文献,进行meta分析。结果截至2008年8月,共纳入21篇文献,其中11篇文献是时间序列研究,10篇文献是病例交叉研究。meta分析提示可吸入颗粒物(PM10)与心血管疾病发作有关(OR=1.008,95%CI=1.006～1.011,P=0.000),同时会增加心血管疾病的死亡风险(OR=1.006,95%CI=1.004～1.009,P=0.000)。结论PM10短期暴露与人群心血管疾病发作、死亡风险存在关联。Objective To evaluate the acute adverse effect of air particulate matter （ PM10 ） pollution on cardiovascular diseases （CVD）. Methods We searched the literatures from PubMed, the Chinese Biomedicine Database （CBM） and China National Knowledge Infrastructure （CNKI）. Additional studies were identified by a hand search of references of original studies. The authors assessed the identified studies according to the criteria of Cochrane. Results A total of 21 studies were identified,including 11 time-series studies and 10 case-erossover studies. Meta-analysis showed that PM10 contributed to the etiology of cardiovascular diseases （CVD） （OR = 1. 008,95% CI = 1. 006 - 1. 011 ,P=0. 000） ,and could increase morbidity rate of cardiovascular diseases （ OR = 1. 006,95% CI = 1. 004 - 1. 009, P = 0. 000）. Conclusion PM10 has an adverse effect on the morbidity and mortality of cardiovascular system.

关 键 词：可吸入颗粒物 心血管疾病 时间序列研究 病例交叉研究 系统评价 

分 类 号：R54[医药卫生—心血管疾病]