功能磁共振成像在累及脑运动皮层区肿瘤手术前后的应用研究  

Application value of functional MRI in pre-and post-operation on patients with tumor near motor cortex

作　　者：王云玲[1] 贾文霄[1] 杨利霞[2] 王红[1] 班允清[1] 丁爽[2] 

机构地区：[1]新疆医科大学第二附属医院,新疆乌鲁木齐830028 [2]新疆医科大学第一附属医院医院影像中心,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2009年第6期679-681,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金资助项目(项目编号:30760062);新疆医科大学科研创新基金

摘　　要：目的:运用功能磁共振成像(fMRI)定位脑功能区,并探讨功能磁共振成像(fMRI)对脑运动皮层区肿瘤的临床应用价值。方法:对20例正常志愿者及30例脑运动皮层区或附近肿瘤患者进行常规及脑功能成像,功能成像方法采用复杂对指运动,并经过计算机后处理获得脑功能区的影像表现,分析肿瘤对功能区的影响。结果:20例健康志愿者均准确显示了运动皮层中枢形态和位置。30例脑肿瘤患者病变侧的运动功能区出现不同程度的减弱、分散,甚至消失。术后脑肿瘤患者运动功能皮层的位置基本恢复正常。结论:BOLD-fMRI是一种有效而无创的脑功能皮层定位方法,对脑功能皮层区肿瘤术前制定手术计划、降低手术风险、选择手术进路等非常有益。Objective： To identify the functional activity areas of motor cortex by functional magnetic resonance imaging （fMRI）, as well as to study the clinical value of fMRI in the patients with brain tumors located near motor cortex. Methods. 20 healthy volunteers and 30 patients with tumors located in or directly near to the motor cortex were checked by routine and functional MRI. The functional images of brain motor cortex obtained by complex finger movements. All the scanning data were analyzed by the statistical method. The fMRI images were analyzed and compared with the pre-operation fMRI. Results： The image of fMRI for 20 healthy volunteers were clear with good functional activity in brain motor cortex. While the pathological changes domain in 30 patients with brain tumors showed weaken, displaced or diffusely distributed, but turned to normal after surgical operation. Conclusion. BOLD fMRI is an effective and non-invasive approach in localizing the motor cortex of brain, which is very helpful in the formulation of surgery planning, to increase the efficiency of surgery, and to reduce the possibility of nerve center injury in surgery.

关 键 词：功能磁共振成像 运动皮层 脑肿瘤 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]