益母草碱对药物流产后大鼠子宫的作用研究  

Effects of leonurine on uterus induced by drug-abortion in rats

作　　者：李霞[1] 陈飞虎[1] 袁凤来[2] 陆伟国[2] 吴繁荣[1] 张燕娜[1] 李晓祥[3] 

机构地区：[1]安徽医科大学药学院 [2]江苏省无锡市第三人民医院 [3]安徽省新星药物开发有限责任公司

出　　处：《中国临床药理学与治疗学》2009年第5期481-486,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究益母草碱(leonurine)对药物流产后大鼠子宫的作用。方法:采用早孕大鼠灌服米非司酮(8.3 mg/kg)和米索前列醇(100μg/kg)造成不完全流产大鼠模型,观察益母草碱对该模型的出血量、出血时间及子宫形态的影响。用光镜观察子宫内蜕膜、绒毛的残留情况,用放免法检测血清雌二醇(E2)、孕酮(P)水平,用BL-420E生物技能实验系统和JH-2型肌张力传感器记录大鼠离体子宫平滑肌的收缩活动。结果:益母草碱能减少子宫出血量(P<0.05),缩短出血时间(P<0.01),明显减少宫内滞留物,增强子宫收缩活动;益母草碱组血清E2水平显著高于模型组(P<0.01)。结论:益母草碱能明显抑制药物流产后大鼠子宫出血,其作用可能与血清E2水平的显著提高及子宫收缩活动的增强有关。AIM： To study the effects of leonurine on uterus induced by drug abortion in rats. METHODS ： Early pregnancy rats were intragastrically （i. g. ） administrated with mifepristone（8.3 mg/kg） and misoprostol（ 100μg/kg） to induce incomplete abortion mod- el. The changes of uterine bleeding amount and time, its morphous were observed in incomplete abortion model rats. The residues of deeidual membranes and chorionic villus were observed with light microscope. The levels of estradiol （E2） and progesterone in blood serum were detected by radioimmunoassay （RIA）, the contraction activity of rat uterine smooth muscle by BL- 420E biological function of the experimental system and JH-2 muscular tension sensor. RESULTS： Compared with model group, leonurine markedly reduced the uterine bleeding amount and time, the intrauterine residues were reduced significantly and the contraction activity of rat uterine smooth muscles was strengthened obviously, the level of E2 in serum was higher （ P 〈 0.01 ）. CONCLUSION： Leonurine has an obvious depressant effect on uterus haemorrhage induced by drug-abortion, which could result from the enhancement of the level of E2 and the contraction activity of rat uterus.

关 键 词：益母草碱 药物流产 子宫 大鼠 

分 类 号：R711[医药卫生—妇产科学]