“肤敏”提取物外用修复皮肤损伤的实验研究  

Experimental study on restoration action of Fum extract on skin destruction

作　　者：毛晓健[1] 赵杰[1] 王敏江[1] 李庆生[1] 

机构地区：[1]云南中医学院

出　　处：《中国临床药理学与治疗学》2009年第5期493-497,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：云南省科技厅重大项目--新药研发专项资助(2004XY04)

摘　　要：目的:观察"肤敏"提取物外用对皮肤损伤的修复作用。方法:采用紫外线照射造成小鼠皮肤损伤模型,比较小鼠体重、皮肤外观变化;测定皮肤中丙二醛(MDA)含量、超氧化物歧化酶(SOD)活力。以氢氧化钠致小鼠皮肤化学烧伤为模型,比较小鼠体重增长率、创面愈合时间。结果:肤敏能有效减轻紫外线照射对皮肤的损伤,降低小鼠皮肤中MDA含量(P<0.05),提高SOD活力。肤敏能维持氢氧化钠烧伤小鼠体重增长,缩短创面愈合时间。结论:"肤敏"提取物外用对紫外线照射造成的皮肤损伤有一定的保护作用,对氢氧化钠致皮肤损伤创面有很好的修复作用。AIM： To observe the restoration action of topical Fum extract （FumE） on skin destruction. METHODS： The skin destruction on rats was caused by ultraviolet radiation. The changes of body weight and skin appearance of rats were compared, and the content of MDA and the activity of SOD were measured. The burn on rats was caused by sodium hydroxide, the growth rate of weight and the healing time were recorded. RESULTS： FumE could relieve the skin destruction caused by ultraviolet radiation, reduce the content of MDA and increase the activity of SOD. FumE could shorten the healing time of rats burned by sodium hydroxide. CONCLUSION： FumE has protective effects on skin destruction caused by ultraviolet radiation, and can repair raw surface caused by sodium hydroxide.

关 键 词：“肤敏”提取物 皮肤损伤 修复 

分 类 号：R965.2[医药卫生—药理学]