妊高征患者口服硝苯地平后脐动脉血流的变化  

Changes of umbilical artery blood flow in pregnancy induced hypertension after oral administration of nifedipine

作　　者：徐明娟[1] 沙金燕[1] 古航[1] 谢红一[1] 费梅[1] 

机构地区：[1]第二军医大学长海医院妇产科

出　　处：《第二军医大学学报》1998年第3期256-258,共3页Academic Journal of Second Military Medical University

摘　　要：目的：观察妊娠高血压综合征（妊高征）患者口服硝苯地平１０ｍｇ后胎盘血流的变化及其不良反应。方法：多普勒超声血流分析仪探测胎儿脐动脉，在口服硝苯地平１０ｍｇ前后，分别取连续５个以上的脐动脉血流速度波５个，计算患者脐动脉收缩期最大血流速度（Ｓ）与舒张期末血流速度（Ｄ）的比值（Ｓ／Ｄ）及阻力系数（ＲＩ），同时观察患者血压（ＢＰ）及脉率的变化。结果：（１）轻、中度妊高征组患者Ｓ／Ｄ、ＲＩ较正常妊娠组无明显变化，而重度妊高征组Ｓ／Ｄ、ＲＩ显著增加（Ｐ＜０．０１）。（２）口服硝苯地平１０ｍｇ后，妊高征患者２０ｍｉｎ后Ｓ／Ｄ、ＲＩ、ＢＰ均无明显变化；４０ｍｉｎ后Ｓ／Ｄ、ＲＩ、ＢＰ均明显减少（Ｐ＜０．０１），脉率增加；重度妊高征组６０ｍｉｎ后Ｓ／Ｄ，ＲＩ，ＢＰ仍有明显改变（Ｐ＜０．０５）。（３）２０％患者服药后有不良反应。结论：硝苯地平有助于减少外周阻力，改善胎盘血流供应。Objective:The changes of placental blood flow were observed after oral administration of nifedipine 10 mg to the patients with pregnancy induced hypertension. Methods:By using color Doppler flow image technique, systolic/diastolic ratio (S/D) and resistance index(RI) of umbilical artery were measured in 15 normal pregnancy and 30 pregnancy induced hypertension patients after oral administration of nifedipine 10 mg, and the changes of blood pressure(BP) and pulse rate were observed at the same time. Results: (1)There were no significant changes of S/D and RI in mild and moderate pregnancy induced hypertension group as compared with control group; marked increase in S/D and RI was observed in severe pregnancy induced hypertension(P<0.01). (2)After treatment with nifedipine 10 mg, S/D and RI had no changes in 20 min, S/D, RI and BP decreased significantly and pulse rate increased in 40 min in the mild and moderate pregnancy induced hypertension groups(P<0.01). S/D, RI and BP had a marked change in 60 min in the severe pregnancy induced hypertension group(P<0.05). Conclusion: Nifedipine could decrease peripheral resistance and increase placental blood volume, so it is effective in the treatment of pregnancy induced hypertension.

关 键 词：硝苯地平 妊娠高血压 脐动脉 药物疗法 血流 

分 类 号：R714.246[医药卫生—妇产科学]