米索前列醇预防剖宫产术后出血的临床研究  

Clinical Study on Reduction of Postpartum Bleeding in Cesarean Section by Misoprostol

作　　者：赵曰孝[1] 厉宣英[1] 彭艳[1] 多晓玲[1] 柴娜冬[1] 

机构地区：[1]山东省济南市第五人民医院妇产科

出　　处：《中华妇产科杂志》1998年第7期403-405,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的观察米索前列醇用于剖宫产预防产后出血的效果。方法选择１８２例剖宫产者，随机分为米索前列醇组、米索前列醇＋催产素组及催产素组。米索前列醇组６０例，术中打开腹膜时口服米索前列醇６００μｇ。米索前列醇＋催产素组６４例，术中打开腹膜时口服米索前列醇６００μｇ，胎儿娩出后宫体肌内注射催产素２０ＩＵ。催产素组５８例，胎儿娩出后宫体肌内注射催产素２０ＩＵ，再静脉滴注催产素２０ＵＩ。以上各组观察术中及术后２小时内出血量。结果术中及术后２小时平均出血量，米索前列醇组为２１２±５６０ｍｌ；米索前列醇＋催产素组为２０８±５５４ｍｌ；催产素组为３４５±６４７ｍｌ。米索前列醇组与催产素组比较，差异有极显著性（Ｐ＜００１）。米索前列醇组与米索前列醇＋催产素组比较，差异无显著性（Ｐ＞００５）。结论米索前列醇促进子宫收缩作用强于催产素，能较好地预防剖宫产术后出血，且用药方便、安全。Objective To observe the effects of misoprostol on reduction of postpartum bleeding in cesarcan section.Methods One hundred and eightytwo cesarean sections were randomized into three groups: misoprostol group (n=60), 600 μg misoprostol was given orally when peritoneum was incised; misoprostol and oxytocin group (n=64), 600 μg misoprostol was given orally and 20 IU oxytocin was injected into uterine muscle immediately after delivery of baby. Oxytocin group (n=58), 20 IU oxytocin was injected into uterine muscle and 20 IU intravenous injection immediately after delivery of baby. The amount of bleeding within 2 hours after delivery was measured.Results The mean amount of bleeding in misoprostol group was 212±56.0 ml, in misoprostol and oxytocin group was 208±55.4 ml, oxytocin group was 345±64.7 ml, respectively. The difference was significant P<0.01 between misoprostol group and oxytocin group, there was no differences between misoprostol group and misoprostol plus oxytocin group. Conclusion Misoprostol is more effective in reduction of postpartum bleeding than that of oxytocin.

关 键 词：剖腹产 产后出血 米索前列醇 预防 

分 类 号：R719.8[医药卫生—妇产科学] R714.461[医药卫生—临床医学]