新生儿肝炎总胆汁酸和甘胆酸测定的临床意义  

Clinical value of Changes of serum total bile acids and choloyglycin in neonatal hepatitis

作　　者：郭文[1] 吴明昌[1] 裴学义[1] 关德华[1] 徐洛 

机构地区：[1]北京儿童医院

出　　处：《北京医学》1998年第4期288-290,共3页Beijing Medical Journal

摘　　要：血清胆汁酸是检测胆汁淤积的敏感指标。我们用酶法比色自动化分析仪测总胆汁酸（ＴＢＡ）和用放免法测甘胆酸（ＣＧ）。对照组为年龄相配的轻症肺炎恢复期患儿。结果：新生儿肝炎急性期的ＴＢＡ及ＣＧ显著增高。至恢复期和治愈期，ＴＢＡ及ＣＧ逐渐下降，与病情转归同步。各期ＴＢＡ及ＣＧ均与对照组比较有显著性差异。急性期ＴＢＡ及ＣＧ与病程呈相关。结果表明ＴＢＡ及ＣＧ有助于判断新生儿病情转归；临床治愈的新生儿肝炎仍可能有轻度胆汁淤积；新生儿肝炎急性期ＴＢＡ越高。Enzymatic-linked colorimetric analysis and radioimmunoassay were performed to detect serum fasting total bile acids(TBA) and choloyglycin(CG) respectively in cases of 32 neonatal hepatitis Control group was agematched mild pneumonia patients in recovery period.Results showed TBA and CG were both elevated in acute period and decreased gradually in convalescent and recovery period.The difference was significant for each stage as compared with controls.Acute TBA correlated strongly with the course.The results suggested that the higher the serum TBA and CG,the longer the course of neonatal hepatitis and cholestasis may exist.

关 键 词：总胆汁酸 甘胆酸 肝炎 新生儿 测定 

分 类 号：R722.139[医药卫生—儿科]