不同血糖状态人群血浆内脂素水平及其相关因素  

Plasma visfatin levels in subjects with different states of glycemia and its related factors

作　　者：李梅[1] 何继瑞[1] 倪安民[1] 

机构地区：[1]兰州大学第二医院干部内科,730030

出　　处：《中华内分泌代谢杂志》2009年第3期297-298,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：空腹血浆内脂素水平在正常糖耐量、糖耐量受损或空腹血糖受损、2型糖尿病组分别为[（17．64±1．37，27．42±1．34和26．55±1．64）μg/L，P〈0．05]，但与肥胖无关。血浆内脂素水平与HbA1c呈正相关（r=0．317，P〈0．01）。多元线性逐步回归分析表明HbA1c、空腹血糖是影响血浆内脂素的独立相关因素。提示血浆内脂素水平与糖代谢状态有关，可能在2型糖尿病的发生、发展中具有一定的作用。Fasting plasma visfatin was determined in subjects with various types of glucose tolerance. Visfatin level was （17.64±1.37 ）μg/L in subjects with normal glucose tolerance, and rose to （27.42± 1.34 ）μg/L（ P〈0.05 ）in those with impaired glucose tolerance or impaired fasting glucose, and to（ 26.55±1.64 ） μg/ L（P〈 0.05 ）in diabetic patients. No difference was found between obese and non-obese subjects. Positive correlation existed between visfatin and HbA1c （ r = 0.317, P〈0.01 ）. Multiple linear step-wise regression showed that HbA1c and fasting plasma glucose had independent relation with the visfatin level. The result suggests that plasma visfatin may be related to glucometabolism and may play a role in the development of type 2 diabetes.

关 键 词：内脂素 糖尿病 2型 肥胖症 

分 类 号：R587.1[医药卫生—内分泌]