GnRHa治疗对中枢性性早熟女孩线性生长和成年身高的影响  

Effects of gonadotropin-releasing hormone analogue on linear growth and final height in girls with central precocious puberty

作　　者：陈少科 唐晴 范歆 郭先鸣 

机构地区：[1]广西妇幼保健院 广西儿童医院儿科,南宁530003

出　　处：《中华内分泌代谢杂志》2009年第3期303-305,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：对82例中枢性性早熟（CPP）女童使用促性腺激素释放激素类似物（GnRHa）治疗后线性生长及终身高进行评价。治疗两年以上患者的第2年生长速度与其治疗第2年和第1年的骨龄差值呈正相关（P〈0．01）。治疗后按骨龄的身高标准等分值增大，预测成人身高提高。随访26例达终身高患者，平均靶身高高于遗传靶身高。故适量的GnRHa治疗辅以有氧运动能够有效地改善CPP女童生长速度及终身高。The effect of gonadotropin-releasing hormone analogue（GnRHa） on linearity growth and final height in 82 girls with central precocious puberty （CPP） was evaluated. The growth velocity in the second year was positively correlated with the difference value of bone age between the first year and the second year after treatment. The height standard deviation score for bone age and predieted adult height increased alter treatment. Twenty-six girls who had been followed to final height obtained better adult height than target height. GnRHa in combination with aerobic exercise increases linear growth and final height in girls with CPP.

关 键 词：促性腺激素释放激素类似物 性早熟 女童 终身高 

分 类 号：R725.8[医药卫生—儿科]