RAS阻断剂对人前脂肪细胞脂联素表达的部位特异性影响  

Regional differences in the response of human preadipocytes to renin-angiotensin system blockers in adiponectin expession

作　　者：雒瑢[1] 田凤石[1] 吴岩[1] 班东杰[1] 

机构地区：[1]天津市公安医院内分泌科,300042

出　　处：《中华内分泌代谢杂志》2009年第3期328-330,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：天津市自然科学基金（07JCYBJC11000）

摘　　要：肾素-血管紧张素系统（RAS）阻断剂可提高体外原代培养的人网膜和皮下前脂肪细胞中脂联素mRNA的表达和蛋白分泌。与噻唑烷二酮类药物相比，RAS阻断剂对网膜来源的细胞具有更强的作用，提示其在以腹型肥胖为特征的代谢综合征干预方面可能具有较大潜力。The adiponectin mRNA expression and secretion of human omental and subcutaneous preadipocytes were increased by renin-angiotensio system （RAS） blockers. Compared with thiazolidinedione, RAS blockers have stronger effects on human omental preadipocytes in adiponectin mRNA expression and secretion, suggesting a potential benefit of RAS blockers on metabolic syndrome with characteristic intra-abdominal obesity.

关 键 词：肾素-血管紧张素系统 人类 前脂肪细胞 脂联素 身体部位 

分 类 号：R589[医药卫生—内分泌]