C反应蛋白在老年COPD急性加重期的临床意义  

Clinical value of CRP in acute aggressive period old patients with COPD

作　　者：陈凤娟[1] 漏德宝 祁慧薇[1] 庄远非[1] 胡辛[1] 张羽萍[1] 高育瑶[2] 

机构地区：[1]上海市第八人民医院呼吸内科,200235 [2]复旦大学附属中山医院肺科

出　　处：《中国临床实用医学》2009年第7期19-20,共2页China Clinical Practical Medicine

摘　　要：目的探讨血清C-反应蛋白（CRP）水平在老年COPD急性加重期的临床意义。方法采用免疫比浊法测定入院前已用过抗生素、糖皮质激素或解热镇痛药的210例老年COPD急性加重期血清CRP水平作为临床研究对象，并以CRP，WBC，ESR和体温在感染控制前后作比较。结果入院前用过抗生素、糖皮质激素或解热镇痛药治疗的老年COPD急性加重期患者血清CRP，WBC，ESR和体温的阳性率分别为92．38％，27．62％，48．57％，和46．67％。CRP水平与WBC，ESR和体温比较差异有显著性（P〈0．01）。老年COPD急性加重期感染控制前后CRP水平为58．66±15．20和8．26±1．24，比较差异有显著性（P〈0．01）。WBC计数在感染控制前后为8．69±2．60和5．34±1．48，比较差异有显著性（P〈0．01）。ESR在感染控制前后为36．81±14．23和24．52±14．61，差异有显著性（P〈0．01）。体温在感染控制前后为37．29±0．780c和36．26±0．370c，差异有显著性（P〈0．01）。结论血清CRP水平可作为老年COPD急性加重期的诊断及临床疗效评估的敏感指标，不受抗生素、糖皮质激素或解热镇痛药的影响。Objective To explore clinical value of C-reactive protein （CRP）in acute aggressive period old patients with COPD. Methods 210 old patients in acute aggressive period with COPD were selected, who used antibiotic,cortin or febrifuge and anodyne before. CRP, WBC, ESR and temperature were detected before and after controlling infection. Results The positive rate of CRP,WBC,ESR and temperature was 92. 38%, 27. 62% ,48.57% and 46.67% respectively. The level of CRP is significant over WBC,ESR and temperature（P 〈 0. 01 ）. The level of CRP were 58.66 ±15.20 and 8.26 ± 1.24 respectively at before and after controlling infection（ P 〈0. 01 ）. The level of WBC were 8.69 ± 2. 60 and 5.34 ± 1.48 respectively at before and after controlling infection（P 〈0. 01 ）. The level of ESR were 36. 81 ± 14. 23 and 24. 52 ± 14. 61 respectively at before and after controlling infection（ P 〈 0. 01 ）. The level of temperature were 37.29 ± 0. 78℃ and 36. 26 ± 0. 37℃ respectively at before and after controlling infection （ P 〈 0. 01 ）. Conclusion CRP is a good marker in acute aggressive period old patients with COPD and it isn＇ t disturbed by antibiotic,cortin or febrifuge and anodyne.

关 键 词：C-反应蛋白 慢性阻塞性肺疾病 急性期 老年人 

分 类 号：R563.9[医药卫生—呼吸系统]