中药熏蒸治疗强直性脊柱炎临床研究  

Clinical Study of Chinese Medicine Fumigation in Treatment of Ankylosing Spondylitis

作　　者：汪东涛[1] 沈鹰[1] 

机构地区：[1]中国人民解放军广州军区总医院,广东广州510010

出　　处：《中国中医药信息杂志》2009年第7期11-13,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：广东省自然科学基金(06019700)

摘　　要：目的观察中药熏蒸治疗强直性脊柱炎(AS)的临床疗效。方法将60例AS患者分为熏蒸组(30例)、非熏蒸组(30例),分析患者治疗前后手指地间距、枕墙距、髋关节前屈、髋关节后伸的变化,观察熏蒸疗法对急性炎症指标血沉(ESR)、C反应蛋白(CRP)的影响;采用酶联免疫法测定治疗前后血清中肿瘤坏死因子α(TNF-α)及白细胞介素-10(IL-10)含量的变化,分析熏蒸疗法对炎性细胞因子表达的影响。结果熏蒸组总有效率为90.0%,非熏蒸组为83.3%;熏蒸组显效率为66.6%,非熏蒸组显效率为33.3%;熏蒸组治疗后手指地间距、枕墙距、髋关节前屈、髋关节后伸均优于治疗前,差异有统计学意义;熏蒸组治疗后ESR、CRP及TNF-α均有显著下降,IL-10显著升高,与非熏蒸组比较,P<0.05或P<0.01。结论中药熏蒸治疗AS具有较好的临床疗效。Objective To observe the clinical efficacy of traditional Chinese medicine fumigation in treating ankylosing spondylitis （AS）. Methods Sixty patients were divided into fumigation group （30 cases） and non-fumigation group （30 cases）, the treatment course was 20 days. The changes of finger pitch, pillow away from the wall, hip flexion, hip extension of the patients and the impact of fumigation on acute inflammation （ESR, CRP） were observed. Enzyme-linked immunosorbent assay was used to determine serum TNF-α and IL-10 before and after treatment to observe the effect of fumigation treatment on inflammatory cytokine expression. Results The total effective rate of treatment group was 90.0% and control group was 83.3%. The efficiency rate of the treatment group was 66.6% and control group was 33.3%. After treatment, finger pitch, pillow away from the wall, hip flexion, hip extension of the treatment group were better than before treatment, the difference was significant. ESR, CRP and TNF-α, IL-10 of the treatment group were significantly decreased compared with the control group （P〈0.05 or P〈0.01）. Conclusion Chinese medicine fumigation treatment has good clinical effect on AS.

关 键 词：强直性脊柱炎 中药熏蒸 临床疗效 

分 类 号：R259.932.3[医药卫生—中西医结合]