丹参川芎嗪注射液对急性冠脉综合征患者血清超敏C反应蛋白及心功能的影响  

Influence of danshen ligustrazin for injection on serum high-sensitivity C-reactive protein and cardiac function of patients with acute coronary syndrome

作　　者：吴国平[1] 黄晓辉[1] 姚震[1] 

机构地区：[1]海南医学院附属医院急诊科教研室,海南海口570102

出　　处：《海南医学院学报》2009年第8期858-860,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020090080)~~

摘　　要：目的:观察丹参川芎嗪注射液治疗急性冠脉综合征(ACS)患者的临床疗效和对ACS患者血清超敏C-反应蛋白(hs-CRP)及射血分数(EF)的影响。方法:98例ACS患者随机分为对照组和治疗组,对照组给予常规西药治疗,治疗组在常规西药治疗基础上加用丹参川芎嗪注射液,另选择健康体检者60例作为正常对照组。于治疗前及治疗10d后测定并比较血清hs-CRP水平,行彩超检查记录射血分数,评价心功能,对疗效进行比较。结果:治疗组心绞痛缓解有效率(96.7%)明显高于对照组(79.2%)(P<0.01);对照组、治疗组治疗前、后血清hs-CRP水平均明显高于正常对照组(P<0.01),治疗组治疗后血清hs-CRP水平明显低于治疗前和对照组(P<0.05～0.01);对照组、治疗组治疗后EF明显高于治疗前(P<0.01),两组间差异无统计学意义(P>0.05)。结论:丹参川芎嗪注射液可有效地缓解ACS患者的心绞痛症状,并能降低血清hs-CRP水平。Objective： To investigate the effect of danshen ligustrazin for injection on the treatment of acute coronary syndrome （ACS） and the influence on serum high-sensitivity C-reactive protein （hs-CRP） and cardiac ejection fraction （EF）. Methods： Ninety-eight patients with ACS were divided randomly into group A and B, and 60 health subjects were selected as group C, patients in group A were treated with western medicine, patients in group B were treated with western medicine as group A and danshen ligustrazin for injection. All patients were determined serum hs-CRP and evaluated ejection fraction with echocardiography 10 d before and after treatment respectively, subjects in group C were determined serum hs-CRP, the parameters determined above were studied. Results： The remission rate of angina pectoris in group B was significantly higher than that in group A （96.7% vs. 79.2%, P 〈0.01 ） ; the serum hs-CRP in group B after treatment was significantly lower than that in group B before treatment and in group C （ P 〈 0.05 ） ; ejection fractions in group B and A after treatment were significantly higher than that before treatment （ P 〈 0.01 ）, the difference between group A and B was no significant （ P 〉 0. 05 ）. Conclusion ： Danshen ligustrazin for injection can effectively alleviate angina pectoris of patients with ACS and reduce serum levels of hs-CRP.

关 键 词：丹参川芎嗪注射液 急性冠脉综合征 超敏C-反应蛋白 

分 类 号：R284.1[医药卫生—中药学] R442.8[医药卫生—中医学]