非洛地平治疗老年高血压合并颈动脉粥样硬化斑块的临床研究  

Clinical study of therapeutic effect of Felodipine on elder hypertension patients with carotid atherosclerosis

作　　者：苏卫红[1] 佟秀梅[2] 孟焱[3] 

机构地区：[1]首都医科大学附属复兴医院干部保健科,100038 [2]首都医科大学附属复兴医院月坛社区卫生站 [3]首都医科大学附属复兴医院超声影像科

出　　处：《北京医学》2009年第7期416-418,共3页Beijing Medical Journal

摘　　要：目的探讨非洛地平对老年高血压患者颈动脉粥样硬化斑块的治疗作用。方法选择老年高血压患者合并颈动脉粥样硬化斑块82例,随机分为非洛地平组(治疗组42例)和盐酸贝那普利组(对照组40例)。用高分辨超声技术检测2组对象的颈动脉内膜中层厚度(IMT)。对2组分别在治疗3个月、9个月及15个月后复查血压和颈动脉IMT。结果2组间血压降低无显著性差异(P>0.05)。但非洛地平组在逆转颈动脉IMT方面优于盐酸贝那普利组(P<0.05)。结论非洛地平除具有良好的降压作用,还具有抗动脉粥样硬化、逆转斑块的作用。Objective To investigate the therapeutic effect of Felodipine on elder hypertension patients with carotid atherosclerosis. Methods 82 cases of elder hypertension patients with carotid atherosclerosis were divided randomly into two groups, the group of treatment and the group of comparison, 42 cases in group of treatment, cured with Felodipine, 40 cases in group of comparison, cured with Benazepril. The inter- media thickness （IMT） were assessed by Doppler ultrasonography. The changes of IMT and blood pressure were observed after 3 months, 9 months and 15 months after therapy. Results Lowing down of Blood pressure were no significant differences between two groups（P 〉 0.05 ）. The IMT was reduced in treatment group, and was significantly different from control group（P 〈 0. 05）. Conclusions Felodipine had good effect in antihypertensive and decrease IMT.

关 键 词：非洛地平 高血压 颈动脉粥样硬化斑块 

分 类 号：R544.1[医药卫生—心血管疾病] R543[医药卫生—内科学]