星点设计-效应面法优选碧血草中卫矛醇的水提工艺  

Optimal Extraction of Melampyrit from Euonymus fortunei by Central Composite Design-Response Surface Methodology

作　　者：韦文俊[1] 刘艳平[1] 

机构地区：[1]广西中医学院药学院,广西南宁530001

出　　处：《中药材》2009年第6期972-974,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:用星点设计-效应面法优选碧血草中卫矛醇的水提取工艺。方法:以溶剂水(倍)量和煎煮时间为自变量,卫矛醇提取量为因变量对自变量各水平进行多元线性回归和二项式拟合,用效应面法选择较佳工艺条件,并进行预测分析。结果:确定最优提取工艺为溶媒用量12倍,提取时间1.5h,提取2次,提取量预测值与理论值偏差为-5.37%,二项式拟合复相关系数r=0.9515。结论:星点设计-效应面法优选碧血草中卫矛醇的水提取工艺,方法简便,预测性良好。Objective： To optimize the process of extracting melampyrit from Euonymus fortunei by central composite design-response surface methodology. Methods： The independent variables were the solvent fold and extractive time, and the dependent variable was the extraction rate of melampyrit from Euonymus fortunei. Then different mathematic models were used to estimate the relationship between the independent and dependent variables. The response surface methodology was used to optimize the process of extraction and the prediction was carried out through comparing the observed and predicted values. Results ： The regression coefficient of binomial fit- ting complex model was 0. 9515, and the optimum conditions of extraction process were 12-fold volume of solvent, 1.5 hours for decoction and 2 times for extraction. The bias between the observed and predicted values was -5.37%. Conclusion： It shows that this method is convenient and the optimum model is highly predictive.

关 键 词：碧血草 星点设计-效应面优化法 卫矛醇 提取工艺 

分 类 号：R284.2[医药卫生—中药学]