汇集滤白细胞血小板的研制及临床应用  

Preparation and clinical application of leukocyte-filtrated platelet concentrate

作　　者：陈龙菊 程亚媛 刘义明 梁其隆 孙天钢[3] 周明欣 

机构地区：[1]广东省茂名市中心血站,广东茂名525000 [2]广东省湛江市第二人民医院,广东湛江524003 [3]广东省高州市人民医院输血科,广东高州525200 [4]广东省高州市中医院血库,广东高州525200

出　　处：《广东医学院学报》2009年第3期242-244,共3页Journal of Guangdong Medical College

摘　　要：目的 评价汇集滤白细胞血小板的质量和临床效果。方法用白膜层法制备手工浓缩血小板，再以60～70mL／min的速度对汇集血小板进行白细胞过滤。30袋汇集滤白细胞血小板过滤前后分别进行血小板含量、白细胞残留量检测和细菌培养，并观察87例出血患者（血液病16例、非血液病71例）输注后24h疗效。结果30袋汇集滤白细胞血小板过滤前后血小板含量差异无统计学意义（P〉0．05），白细胞残留量差异有统计学意义（P〈0．01），细菌培养均为阴性。非血液病出血患者输注汇集滤自细胞血小板的有效率是85．9％，而血液病患者输注有效率是75．0％。结论汇集滤白细胞血小板质量指标均达到单采血小板国家质量标准，临床应用效果良好。Objective To evaluate the quality and clinical effectiveness of leukocyte-filtrated platelet concentrate. MethOds The platelet concentrate was prepared manually by buffy coat, and then filtrated at the speed of 70 mL/min for removal of leukocyte. Thirty bags of platelet concentrates were detected by platelet and WBC count and bacterial culture before and after leukocyte filtration. The 24-h clinical efficacy in 87 patients with hemorrhagic disease （hematologic diseases, 16; non-hematologic diseases, 71）was observed after infusion of leukocyte-filtrated platelet concentrate. Results Platelet count remained intact （P〉 0.05）and bacterial culture was negative, but WBC count decreased obviously （P〈0.01）after leukocyte filtration in 30 bags of platelet concentrates. The effective rates were 85.9 % and 75.0 % in non-hematologic and hematologic patients, respectively. Conclusion The quality of the leukocyte-filtrated platelet concentrate meets the state criterion for single-sampling platelet, and its clinical efficacy is satisfactory.

关 键 词：白细胞过滤 汇集血小板 临床应用 白膜层法 

分 类 号：R331.143[医药卫生—人体生理学]