Neuronal signal detecting and stimulating circuit array for monolithic integrated MEA  

用于单片集成MEA系统的神经信号探测电路和激励电路阵列(英文)

作　　者：谢书珊[1] 王志功[1] 潘海仙[2] 吕晓迎[2] 

机构地区：[1]东南大学射频与光电集成电路研究所,南京210096 [2]东南大学生物电子学国家重点实验室,南京210096

出　　处：《Journal of Southeast University(English Edition)》2009年第2期175-179,共5页东南大学学报（英文版）

基　　金：The National Natural Science Foundation of China (No.90307013,90707005);the Natural Science Foundation of Jiangsu Province(No. BK2008032);Open Foundation of State Key Laboratory of Bio-Electronics of Southeast University

摘　　要：A neuronal signal detecting circuit and a neuronal signal stimulating circuit designed for a monolithic integrated MEA（micro-electrode array） system are described. As a basic cell of the circuits, an OPA（ operational amplifier） is designed with low power, low noise, small size and high gain. The detecting circuit has a chip area of 290 μm × 400 μm, a power dissipation of 2.02 mW, an equivalent input noise of 17.72 nV/ Hz, a gain of 60. 5 dB, and an output voltage from - 2. 48 to ＋ 2. 5 V. The stimulating circuit has a chip area of 130 μm × 290 μm, a power dissipation of 740 μW, and an output voltage from - 2. 5 to 2. 04 V. The parameters show that two circuits are suitable for a monolithic integrated MEA system. The detecting circuit and MEA have been fabricated. The test results show that the detecting circuit works well.介绍了单片集成MEA系统和用于该系统的神经元信号探测电路和激励电路,基本单元电路是低功耗、低噪声、高增益和小版图尺寸的运算放大器.详细讨论了探测电路、激励电路和基本单元运算放大器的设计.神经元信号探测电路版图面积290μm×400μm,功耗2.02mW,等效输入噪声17.72nV/Hz,增益60.5dB,输出电压摆幅-2.48～+2.5V.激励电路版图面积130μm×290μm,功耗740μW,输出电压摆幅-2.5～2.04V.参数表明这2种电路适用于单片集成MEA系统.探测电路和单片集成MEA系统已经流片.探测电路的测试结果表明电路工作正常.

关 键 词：neuronal signal detecting noise micro-electrode array （ MEA ） complementary metal-oxide-semiconductor transistor （CMOS） technology 

分 类 号：TN722.7[电子电信—电路与系统] Q421[生物学—神经生物学]