养阴生血饮防治辐射损伤的实验研究  

An Experiment Study on the Radioprevention of Yangyin Shengxie Formula

作　　者：吴振宇[1] 张杰[1] 王正森 李承军[1] 吴志奎[1] 陆军[1] 

机构地区：[1]中国中医研究院广安门医院基础医学研究室

出　　处：《中国实验方剂学杂志》1998年第4期22-25,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金

摘　　要：采用钴照射的动物模型及其体外生化及免疫分析方法，探讨了养阴生血饮的药理作用。结果表明养阴生血饮能提高致死剂量照射动物３０ｄ和小剂量多次照射６０ｄ及荷瘤小鼠１次照射后２０ｄ的存活率；能增加超氧化物岐化酶的活性；降低过氧化脂质的水平；减少细胞的微核形成；促进脾细胞ＤＮＡ修复；诱导脾细胞产生白细胞介素－２；The pharmacological effect of Yangyin Shengxie Formula(YYSXF)was invistigated in the experimental animals irradiated with the 60 Co γ rays and in an in vitro biochemical and immunological systems. The results showed YYSXF could raise survival rate of the mice after irradition, increase activity of superoxide dismutose (SOD) and reduce quantity of the lipid peroxide (LPO) in liver and red blood cell, extenuate micronucleus formating in V79 4 cell, promote unscheduled DNA synthesis and induce production of interleukin 2 in spleen cells and protect bone marrow cells in mice.

关 键 词：养阴生血饮 辐射损伤 DNA修复 IL-2 微核形成 

分 类 号：R818.705[医药卫生—放射医学]