不同药物对心理应激猕猴的抗应激作用(英文)  

Study on AntiPsychological Stress of Different Drugs in [WT2”BX〗Macaca mulutta

作　　者：张力跃[1,2] 江燕[1,2] 田保平[1,2] 马原野 王桂兰[1,2] 

机构地区：[1]中科院昆明动物所 [2]云南大学生物系

出　　处：《云南大学学报（自然科学版）》1998年第3期197-199,共3页Journal of Yunnan University(Natural Sciences Edition)

摘　　要：本文以心理应激猕猴为动物模型，比较研究了猕猴应激前后外周血中ＡＣＴＨ、皮质醇、胰岛素以及游离Ｔ３，Ｔ４的变化，并对安定、心得安等药物的抗应激效应进行了初步的探讨．实验结果表明，在应激前后，ＡＣＴＨ、皮质醇呈显著性差异（Ｐ＜０．０５和Ｐ＜０．０１），胰岛素呈上升趋势．安定可使应激动物的ＡＣＴＨ、皮质醇的水平明显降低（Ｐ＜０．０５），但是，对ＦＴ３，ＦＴ４的影响不明显．心得安对各种激素无明显影响．The Macaca mulutta under the status of psychological stress was made as the animal model.And the corticotropin,cotison,insulin and FT3,FT4 in the plasama were comparitively investigated. The results were as forllows:1.The concentrations of the ACTH and cotison appeard significantly difference before and after the stress([WT5”BX〗P<0.05 and P<0.01),and the concentration of insulin increased after the stress.2.Diazepam greatly reduced the ACTH and cotison of monkey under stress (P<0.05),but propranolol had not apparent effect on the above hormoms.3.The concentration of FT3 and FT4 had few changes ether stress or antistress.

关 键 词：猕猴 应激 皮质醇 安定 心得安 抗应激作用 

分 类 号：R977[医药卫生—药品] R971[医药卫生—药学]