左归丸对MSG-大鼠胸腺及淋巴细胞增殖反应的影响  

Effect of Zuogui Pill on the Thymus and Lymphocyte Proliferation in Rats Treated with MSG Neonatally

作　　者：刘彦芳[1] 蔡定芳[1] 陈晓红[1] 沈自尹[1] 

机构地区：[1]上海医科大学华山医院

出　　处：《中国实验方剂学杂志》1998年第4期1-3,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金;卫生部科学研究基金

摘　　要：新生期大鼠给予左旋谷氨酸单钠（ＭＳＧ）损害下丘脑弓状核（ＡＲＣ），成年后大鼠除表现生长发育迟缓外，还可见到胸腺体积缩小、重量减轻，脾脏Ｔ淋巴细胞对Ｃｏｎ－Ａ诱导的增殖反应减弱。滋补肾阴代表名方左归丸能明显改善ＭＳＧ－大鼠的胸腺与淋巴细胞增殖反应的异常。提示：１．下丘脑弓状核参与细胞免疫功能的调节；２．The adult rats that were treated with monosodium glutamate (MSG) neonatally to cause a lesion of arcuate nucleus (ARC) in the hypothalamus, showed smaller and lighter thymus and inhibited spleen T lymphocyte proliferation (LPR), apart from retarded growth. After the treatment with the adult MSG rats with Zuogui pill, a TCM presoription nourishing and recuperating the Kidney Yin, we found inhibited cellular immunity was reversed to some extent.It suggested 1.ARC may be a regulator of cellular immunity; 2.Zuogui pill can redress the abnomality of the thymus and LPR.

关 键 词：左归丸 胸腺 弓状核 淋巴细胞增殖 MSG 

分 类 号：R286.0[医药卫生—中药学]