比色法测定罗红霉素氨溴索干混悬剂的溶出度  

Dissolution Test of Roxithromycin and Ambroxol Hydrochloride for Oral Suspension by Colorimetric Method

作　　者：孙峰[1] 姚宏涛 

机构地区：[1]沈阳东陵药业股份有限公司,沈阳110161 [2]沈阳市山日药物研究所,沈阳110015

出　　处：《中国药品标准》2009年第3期225-228,共4页Drug Standards of China

摘　　要：目的:建立罗红霉素氨溴索干混悬剂的溶出度测定方法。方法:采用比色法测定罗红霉素氨溴索干混悬剂的溶出量。结果:罗红霉素在60～100 mg.L-1的浓度范围内峰线性关系良好(R2=0.999 9),平均回收率在99.41%(n=9)。结论:该方法准确可靠,简单快速,可用于罗红霉素氨溴索干混悬剂的溶出度的测定。Objective：To establish a colorimetric method for dissolution Test of Ambroxol Hydrochloride for Oral Suspension. Methods ： A colorimetric method was used in the dissolution Test. Results： The linear range for Roxithromycin was 60 - 100 mg · L^-1 （ R^2 = 0. 999 9 ）, the average recovery of Roxithromycin was 99.41% （ n = 9 ）. Conclusion： A simple, rapid and accurate method for dissolution Test of Roxithromycin and Ambroxol Hydrochloride for Oral Suspension is established.

关 键 词：罗红霉素氨溴索干混悬剂 溶出试验 比色法 

分 类 号：R446.11[医药卫生—诊断学] R978.15[医药卫生—临床医学]